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Pancreatic Cyst DNA Analysis

18 Years
Not Enrolling
Pancreatic Cyst, Pancreatic Pseudocyst, Pancreatic Neoplasm

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Trial Information

Pancreatic Cyst DNA Analysis

The study of pancreatic diseases is hindered by the organ's deep seated location and
especially lack of symptoms during the early stages of disease development and progression
e.g. pancreatic cancer. This is particularly true of pancreatic cysts, the variety and the
malignant potential of which encompass a broad spectrum. The radiological features
distinguishing a benign from a pre-malignant to a frankly malignant cyst in the pancreas are
frequently underwhelming and have lead to the clinical practice of sampling all but the most
obvious. The yield of the aspirate in turn is frequently not of a quality upon which a
clinical decision can be based.

Most would agree that the best approach for management of pancreatic cystic neoplasm lies in
early diagnosis, ideally at a precancerous stage. The effectiveness and applicability of
this study is the based on the ability of the cyst DNA analysis to stratify the patients at
risk of developing pancreatic cancer based on the extent of accumulated mutational damage.

Inclusion Criteria:

- Previously scheduled for Endoscopic ULtrasound for evaluation of pancreatic cyst

Exclusion Criteria:

- Any condition that would preclude safe performance of EUS/FNA

Type of Study:


Study Design:

Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal, Time Perspective: Retrospective/Prospective

Principal Investigator

Asif Khalid, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Pittsburgh


United States: Food and Drug Administration

Study ID:




Start Date:

June 2004

Completion Date:

Related Keywords:

  • Pancreatic Cyst
  • Pancreatic Pseudocyst
  • Pancreatic Neoplasm
  • Pancreatic Cyst
  • PANDA Study
  • Neoplasms
  • Cysts
  • Pancreatic Cyst
  • Pancreatic Neoplasms
  • Pancreatic Pseudocyst



Medical University of South CarolinaCharleston, South Carolina  29425-0721
Washington University Medical CenterSaint Louis, Missouri  63105
University of PittsburghPittsburgh, Pennsylvania  15261
University of PennsylvaniaPhiladelphia, Pennsylvania  19104
Indiana University - Purdue University IndianapolisIndianapolis, Indiana  46202
Partners HealthCare SystemBoston, Massachusetts  02114
VA Pittsburgh Healthcare SystemPittsburgh, Pennsylvania  15240