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Influence of Obstructive Sleep Apnea on Humoral and Cell-Mediated Vaccine Responses


N/A
18 Years
N/A
Not Enrolling
Both
Obstructive Sleep Apnea

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Trial Information

Influence of Obstructive Sleep Apnea on Humoral and Cell-Mediated Vaccine Responses


Inclusion Criteria:



- Absence of any immunocompromising diseases or medical conditions

- Not taking any immune modifying medications or supplements

- Significant obstructive sleep apnea as verified by complete overnight polysomnography
with apnea-hypopnea index (AHI) > 15 events per hour (sleep apnea subjects)

- Free of sleep disordered breathing verified by complete overnight polysomnography
(AHI < 5 events per hour) or oximetry (< 5 desaturations per hour) (control subjects)

Exclusion Criteria:

- Documented history of allergy to influenza vaccine or any of its components

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label

Outcome Measure:

The primary outcome variable will be mean lymphocyte interferon- ÿ (IFN- ÿ) production at 14 days (measured by ELISA)

Principal Investigator

John M Dopp, PharmD

Investigator Role:

Principal Investigator

Investigator Affiliation:

University of Wisconsin, Madison

Authority:

United States: Institutional Review Board

Study ID:

2003-284

NCT ID:

NCT00214071

Start Date:

October 2004

Completion Date:

June 2006

Related Keywords:

  • Obstructive Sleep Apnea
  • Apnea
  • Sleep Apnea Syndromes
  • Sleep Apnea, Obstructive

Name

Location
University of Wisconsin Madison,, Wisconsin  53792-5666