Inclusion Criteria:

- Signed and dated written informed consent

- Confirmed stage II or III (TNM)

- Patient with curative surgery for colorectal adenocarcinoma

- Total digestive endoscopy prior or post surgery.

- Age > 18 years old

- Normal liver ultrasound and chest X-ray or thoraco-abdomino pelvic computed
tomography (CT) scan.

- In fertile women, efficient contraception or postmenopausal patient (amenorrhea for
at least 1 year)

Exclusion Criteria:

- Serious concomitant pathology

- Uncontrolled diabetes with a classical treatment (glycaemia >1.4 g/l)

- Other malignant tumour within the last 5 years (except for curatively treated
basocellular carcinoma of the skin or in situ cervical carcinoma).

- Uncontrolled infection

- Women who are pregnant or lactating

- Inability to understand informed consent

- Psychological or geographic impossibility to follow up for three years.