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Bone Loss in Men on Androgen Blockade as Adjuvant Therapy for Prostate Cancer


N/A
40 Years
N/A
Not Enrolling
Male
Prostate Cancer, Bone Loss

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Trial Information

Bone Loss in Men on Androgen Blockade as Adjuvant Therapy for Prostate Cancer


Inclusion Criteria:



- Men

- Age of 40 years or greater

- Diagnosis of advanced prostate cancer (ie: prostate-specific antigen [PSA] less than
25 ug/L and undergoing continued treatment with leuteinizing hormone-releasing
hormone [LHRH] therapy)

- Willing and able to consent

Exclusion Criteria:

- Metastatic disease to bone

- Medications affecting bone turnover (bisphosphonate, steroids, anticonvulsant)

- Renal failure (serum creatinine > 200 umol/L)

- Co-morbidity factors affecting bone density (ie: Paget's, rheumatoid arthritis)

- Factors affecting ability to perform the bone density tests using femoral head
measurements (ie: bilateral hip arthroplasty)

- Cancer other than skin, except when, in the investigators' opinion, it is determined
to be appropriate and not adversely affect the outcome of the trial

- Gastrointestinal (GI) pathology (eg. malabsorption syndrome)

- Parathyroid disease

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Principal Investigator

Hassan Razvi, MD, FRCSC

Investigator Role:

Principal Investigator

Investigator Affiliation:

Urology, St. Joseph's Hospital, University of Western Ontario

Authority:

Canada: Health Canada

Study ID:

R-05-055

NCT ID:

NCT00199537

Start Date:

February 2005

Completion Date:

February 2008

Related Keywords:

  • Prostate Cancer
  • Bone Loss
  • Prostatic Neoplasms

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