Trial Information

Effects of Pro-Inflammatory and Anti-Inflammatory Cytokine Gene Polymorphism on the Development of Gastric Cancer and Peptic Ulcer in Japanese

H. pylori infection has close associations with the development of peptic ulcer diseases as
well as gastric cancer, gastric adenoma, and gastric MALT lymphoma. The association of the
host genetics with the susceptibility to various gastroduodenal disorders has been
intensively investigated in the pathogenesis of peptic ulcer and gastric cancer by H. pylori
infection .

In chronic active gastritis induced by H. pylori infection, activated neutrophils and
mononuclear cells produce several pro-inflammatory and anti-inflammatory cytokines. In fact,
levels of pro-inflammatory and anti-inflammatory cytokines are elevated in gastric mucosa
infected with H. pylori.

Cytokine polymorphisms are associated with various inflammatory and autoimmune diseases.
Recently, cytokine polymorphisms are considered to play an important role in the
pathogenesis of peptic ulcer and gastric cancer. However, the roles of the IL-10
polymorphisms on the pathogenesis of H. pylori-related gastric cancer and peptic ulcer have
not been fully elucidated.It is unclear whether pro-inflammatory and anti-inflammatory
cytokines polymorphisms were associated with pathogenesis of peptic ulcer and gastric cancer
in Japan. Then, we intended to clarify the association between polymorphisms of IL-10 and
the susceptibility to gastric cancer, gastric ulcer and duodenal ulcer in Japan, and to
detect the individuals who have higher risks for gastrointestinal disease development.