Evaluation of Multimodality Breast Imaging: Project 3-Lesion Staging
- Compare the ability of digital mammography, ultrasound, MRI, and fludeoxyglucose F 18
positron emission tomography (FDG-PET) in depicting the extent of the index lesion
within an affected breast in women with newly diagnosed breast cancer.
- Compare the ability of digital mammography, ultrasound, MRI, and FDG-PET in identifying
additional foci of cancer in the affected breast.
- Estimate the accuracy of FDG-PET in predicting the status of the axillary lymph nodes,
using sentinel node sampling as the gold standard.
- Determine whether diffuse or multifocal cancers detected on MRI, ultrasound, digital
mammography, and FDG-PET can be predicted based on mammographic, clinical, or
- Based on correlation of various imaging techniques and clinical and pathological
findings, generate a profile of patients at risk for mammographically and clinically
occult, diffuse or multifocal disease.
- Collect pilot data on the accuracy of digital tomosynthesis in determining the extent
of breast cancer (in women consenting to the contrast-enhanced tomosynthesis study).
OUTLINE: This is a prospective study. Patients are stratified according to breast density
(fatty vs scattered/less than 50% dense vs heterogeneously dense/greater than 50% dense vs
extremely dense), presentation (palpable abnormalities vs imaging abnormalities only), and
image findings (density vs calcification).
Patients undergo MRI, ultrasound, digital mammography, and fludeoxyglucose F 18 positron
emission tomography. Results of imaging are compared by a panel of physicians to determine
efficacy of each method. Consenting patients also undergo digital tomosynthesis with or
without contrast enhancement.
PROJECTED ACCRUAL: A total of 400 patients will be accrued for this study.
Masking: Open Label, Primary Purpose: Diagnostic
Size of the index lesion (3 dimensions and tumor volume)
Abass Alavi, MD
Abramson Cancer Center of the University of Pennsylvania
United States: Federal Government
|Abramson Cancer Center of the University of Pennsylvania||Philadelphia, Pennsylvania 19104-4283|