Inclusion Criteria:

To be included in this study, you must meet the following criteria:

- Adenocarcinoma of the breast confirmed by biopsy

- Female Patients >18 years of age

- Normal cardiac function

- Ability to perform activities of daily living with minimal assistance

- Chemotherapy naïve or have received prior chemotherapy > 5 years ago

- Adequate bone marrow, liver and kidney function

- Be informed of the investigational nature of this study

- Sign an informed consent form

- Sentinel lymph node and/or axillary dissection prior to enrollment

Exclusion Criteria:

You cannot participate in this study if any of the following apply to you:

- Life expectancy of < than 6 months

- History of significant heart disease

- Prior chemotherapy or hormonal therapy

- Concurrent Trastuzumab therapy

- History of significant psychiatric disorders

- History of active uncontrolled infection

Please note: There are additional inclusion/exclusion criteria. The study center will
determine if you meet all of the criteria. If you do not qualify for the trial, study
personnel will explain the reasons. If you do qualify, study personnel will explain the
trial in detail and answer any questions you may have.