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A Phase II Study of Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer

Phase 2
18 Years
70 Years
Open (Enrolling)
Nasopharyngeal Neoplasms

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Trial Information

A Phase II Study of Intensity Modulated Radiation Therapy for Nasopharyngeal Cancer

Inclusion Criteria:

- Confirmed histopathologic diagnosis of nasopharyngeal squamous cell carcinoma
requiring primary radiation

- less than 70 yrs of age

- Stage T1-T4; N0-N3; M0

- KPS less than 70

- no prior RT to H&N or chemotherapy for H&N

- no other malignancy except non-melanomatous skin cancer

- no distant mets

- no contraindication to RT or chemotherapy

- adequate organ function

- informed consent

Exclusion Criteria

- Major medical or psychiatric illness, which would interfere with either completion of
therapy and follow-up or with full and complete understanding of the risks and
potential complications of the therapy.

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

The primary objective of this study is to evaluate 3 year local progression free survival in patients with nasopharyngeal carcinoma treated with Intensity Modulated Radiation Therapy (IMRT) techniques.

Principal Investigator

Andrew Bayley, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Princess Margaret Hospital, Canada


Canada: Ethics Review Committee

Study ID:

UHN REB 03-0158-C



Start Date:

June 2003

Completion Date:

Related Keywords:

  • Nasopharyngeal Neoplasms
  • Neoplasms
  • Head and Neck Neoplasms
  • Nasopharyngeal Neoplasms