Inclusion Criteria:

- Age : 18 years or older

- Histologically or cytologically proven Burkitt lymphoma according to the WHO
classification

- WHO performance < 3

- Informed consent

Exclusion Criteria:

- Known HIV positive infection

- Positive serology for HCV and HBV (except after vaccination)

- Patients previously treated for lymphoma

- cardiac disease that contradict anthracycline chemotherapy

- Psychological or psychiatric condition who contradict steroids therapy

- Patients with serious renal failure unrelated to the lymphoma (serum creatinin level
higher than 150 mmole/L)

- Cirrhosis or severe hepatic failure unrelated to the lymphoma

- Previous malignant disease except basal cell skin carcinoma or in situ uterine cervix
carcinoma

- Any psychological, familial, sociological or geographical condition potentially
hampering compliance with the study protocol and follow-up schedule

- Primary organ transplant or other immunosuppressive conditions Pregnancy