Inclusion Criteria:

- Patients must be less than (<) 18 years of age with a diagnosis of Fanconi anemia.

- Patients must have an HLA-A, B, DRB1 identical unrelated donor or less than or equal
to (≤)1 antigen mismatched related (non-HLA-matched sibling) or <1 antigen mismatched
unrelated UCB donor. Patients and donors will be typed for HLA-A and B using
serological or molecular techniques and for DRB1 using high resolution molecular
typing.

- Patients with FA must have aplastic anemia (AA), myelodysplastic syndrome without
excess blasts, or high risk genotype as defined below.

- Aplastic anemia is defined as having at least one of the following when not
receiving growth factors or transfusions

- Platelet count <20 x 10^9/L

- ANC <5 x 10^8/L

- Hgb <8 g/dL

- Myelodysplastic syndrome with multilineage dysplasia with or without chromosomal
anomalies

- High risk genotype (e.g. IVS-4 or exon 14 FANCC mutations, or BRCA1 or 2
mutations)

- Adequate major organ function including

- Cardiac: ejection fraction greater than (>)45%

- Hepatic: bilirubin, AST/ALT, ALP <2 x normal

- Karnofsky performance status >70% or Lansky performance status >50%

- Women of child-bearing age must be using adequate birth control and have a negative
pregnancy test

Exclusion Criteria:

- Available HLA-genotypically identical related donor

- History of gram negative sepsis or systemic fungal infection (proven or suspected
based on radiographic studies)

- Refractory anemia with excess blasts, or leukemia

- Active central nervous system (CNS) leukemia at time of hematopoietic cell transplant
(HCT)

- History of squamous cell carcinoma of the head/neck/cervix within 2 years of HCT

- Pregnant or lactating female

- Prior radiation therapy preventing use of total body irradiation (TBI) 450 centigray
(cGy)