Know Cancer

forgot password

Breast MRI Screening in Women Treated With Mediastinal Irradiation for Hodgkin's Disease

20 Years
Not Enrolling
Breast Cancer, Hodgkin's Disease

Thank you

Trial Information

Breast MRI Screening in Women Treated With Mediastinal Irradiation for Hodgkin's Disease

- The screening breast MRI and mammography will be performed 6 months or longer after the
last mammogram. For pre-menopausal women, the screening will be performed during the
second week of the menstrual cycle to reduce cycle-related breast changes. As much as
possible, the breast MRI and mammogram are to be performed on the same day.

- On the day of the breast imaging studies, the patient will also be asked to fill out a
baseline breast health questionnaire, which includes questions on time since radiation
therapy, prior screening history, history of prior benign breast biopsies, menopausal
status, prior hormonal therapy use, etc.

- In patients with suspicious findings or findings highly suggestive of malignancy, the
abnormal findings will be reviewed with the patient and recommendations will be made
for a biopsy.

Inclusion Criteria:

- Female patients treated with radiation therapy to the chest area for Hodgkin's

- Age between 12 and 35 at initial treatment

- Eight years or longer after initial treatment

- Pre-approval from the participant's insurance company for the breast imaging studies

Exclusion Criteria:

- Pregnant or lactating women

- Post Bilateral mastectomy

- Currently undergoing breast cancer therapy

- Known metastatic cancer

- Patients with contraindications for undergoing an MRI: cardiac pacemaker, known
metallic objects in body e.g. metallic clips, bullets, shrapnel or buckshots.

Type of Study:


Study Design:

Observational Model: Case-Only, Time Perspective: Prospective

Outcome Measure:

To compare the sensitivity, specificity, positive and negative predictive value of mammography and breast MRI for breast cancer detection in women treated for Hodgkin's disease.

Outcome Time Frame:

5 years

Safety Issue:


Principal Investigator

Andrea K. Ng, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Dana-Farber Cancer Institute


United States: Institutional Review Board

Study ID:




Start Date:

July 2005

Completion Date:

May 2010

Related Keywords:

  • Breast Cancer
  • Hodgkin's Disease
  • Breast screening
  • Breast MRI
  • Mammogram
  • Mammography
  • Breast Neoplasms
  • Hodgkin Disease



Beth Israel Deaconess Medical Center Boston, Massachusetts  02215
Brigham and Women's Hospital Boston, Massachusetts  02115
Dana-Farber Cancer Center Boston, Massachusetts  02115