A Phase II Trial of Capecitabine and Thalidomide in Previously Treated Metastatic Colorectal Carcinoma
18 Years
N/A
Both
Colorectal Adenocarcinoma
Trial Information
A Phase II Trial of Capecitabine and Thalidomide in Previously Treated Metastatic Colorectal Carcinoma
- Patients will take capecitabine orally twice a day for two weeks followed by a one week
break period. These three week cycles will continue as long as the patient continues
to benefit from the the therapy and does not experience intolerable side effects.
- Thalidomide will be taken orally once daily in the evening. Each week teh daily dose
of the medication will be increased by 100mg as long as the patient is not experiencing
any moderate to severe side effects. The dose will be increased in this manner until
the daily dose is 600mg. If side effects do develop, the dose will either be held
constant or decreased until the side effects resolve. If the side effects do not
resolve, treatment will be stopped.
- Before starting treatment and periodically throughout the study, a physical exam,
routine blood tests, scans and x-rays will be done to monitor the body's response to
the treatment.
- For women patients, pregnancy tests will be performed every 3 weeks while on therapy.
- Scans and x-rays will be performed every 9 weeks (after every 3 cycles of treatment) to
follow the effects of the study drugs on the tumor.
Inclusion Criteria:
- Histologic proof of colorectal adenocarcinoma with radiological or cytological
evidence of stage IV (metastatic) disease
- Measurable tumor
- Serum creatinine < 1.5 mg/dl
- Total bilirubin < 2.0 mg/dl
- AST < 5 x ULN
- ANC > 1,500/mm3
- Platelets > 100,000/mm3
- Hemoglobin > 9.0 gm/dl
- Must have received at least one prior chemotherapy regimen for metastatic colorectal
cancer. At least 3 weeks must have passed since the last chemotherapy treatment
- 18 years of age or older
- ECOG performance status of less than or equal to 2
- Life expectancy of greater than 12 weeks
Exclusion Criteria:
- Prior treatment with mitomycin C or nitrosourea compounds
- Prior treatment with capecitabine or thalidomide
- Clinically apparent central nervous system metastases or carcinomatous meningitis
- Peripheral neuropathy of grade 2 or greater severity
- Myocardial infarction in the past 6 months
- Major surgery in the past 2 weeks
- Uncontrolled serious medical or psychiatric illness
- Pregnant or lactating women
- Concurrent malignancy of any site, except limited basal cell carcinoma or squamous
cell carcinoma of the skin or carcinoma in situ of the cervix.
- Known allergy to 5-FU
Type of Study:
Interventional
Study Design:
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Outcome Measure:
To assess the anti-tumor activity of capecitabine and thalidomide when administered to patients with previously treated metastatic colorectal cancer.
Principal Investigator
Charles S. Fuchs, MD, MPH
Investigator Role:
Principal Investigator
Investigator Affiliation:
Dana-Farber Cancer Institute
Authority:
United States: Institutional Review Board
Study ID:
01-141
NCT ID:
NCT00165217
Start Date:
November 2001
Completion Date:
December 2005
Related Keywords:
- Colorectal Adenocarcinoma
- capecitabine
- thalidomide
- colorectal cancer
- Adenocarcinoma
- Adenocarcinoma, Mucinous
- Carcinoma
- Colorectal Neoplasms
Name | Location |
|---|---|
| Dana-Farber Cancer Institute | Boston, Massachusetts 02115 |
| Massachusetts General Hospital | Boston, Massachusetts 02114-2617 |
