Dosimetric Analysis of Vaginal Cuff Brachytherapy in Endometrial Carcinoma
- This study is separated into 2 phases. In phase 1, patients will be asked to have
their bladder full for the second planned insertion of the brachytherapy applicator and
empty for the third insertion. For phase 2, the effect of cylinder angle on normal
tissue dosimetry will be investigated. Of the two bladder states assessed in phase 1
(empty or full), the one deemed to give the lower dose to the total amount of bladder
tissue will be considered the standard and applied to all patients in phase 2.
- In phase 1, to standardize bladder filling, patients will be asked to empty their
bladder, then to drink 32 oz of water one and a half hours before the CT scan. The
patient will undergo a treatment-planning scan after the brachytherapy cylinder is
inserted and before brachytherapy treatment.
- In phase 2, patients will be asked to fill or empty their bladder according to the
results of phase 1. The vaginal cylinder will be placed horizontally for the second
treatment. The cylinder will then be angled at a specific angle for the subsequent
- A history and physical exam will be performed within 2 weeks of study entry, then at 14
days, 90 days, and 180 days following the completion of therapy.
Observational Model: Case-Only, Time Perspective: Prospective
Akila Viswanathan, MD, MPH
Dana-Farber Cancer Institute/Brigham and Women's Hospital
United States: Institutional Review Board
|Dana-Farber Cancer Institute||Boston, Massachusetts 02115|
|Brigham and Women's Hospital||Boston, Massachusetts 02115|