Inclusion Criteria:

- Histologically confirmed uterine sarcoma (rereading in reference centers)

- Leiomyosarcoma, adenosarcoma, carcinosarcoma and high grade endometrial stromal
sarcoma

- All stages <= stage III (FIGO modified for endometrial carcinoma)

- Full surgical exeresis

- Age >= 18 years and physiological age <= 65 years

- Negative extension check-up (thoracic and abdomino-pelvic TDM)

- Performance status (PS) <= 2 (ECOG)

- Normal haematologic functions (absolute neutrophil count > 1,500/mm3, platelets >
100,000/mm3)

- Serum creatinine < 1.25 x ULN

- Good hepatic check-up (total serum bilirubin < 1.5 x ULN; AST or ALT < 2.5 x ULN)

- Absence of neuropathy > grade 1

- Left ventricular ejection fraction > 50% (by isotopic or ultrasound scan
determination)

- Written informed consent

Exclusion Criteria:

- Low grade endometrial stromal sarcoma

- Time since surgery > 8 weeks

- Specific contraindications to the studied treatment (cardiac, kidney, or hepatic
ones)

- Antecedents or evolutive psychiatric disorder

- Concurrent active infection or other serious uncontrolled systemic disease

- Antecedents of cancer but a cutaneous basocellular one or an in situ epithelioma of
the cervix