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Validation of 18F-MISO-PET and 18F-FLT-PET by Immunohistochemical Assessment of Head and Neck Cancer Resection Specimen


Phase 1
18 Years
N/A
Open (Enrolling)
Both
Head and Neck Neoplasms

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Trial Information

Validation of 18F-MISO-PET and 18F-FLT-PET by Immunohistochemical Assessment of Head and Neck Cancer Resection Specimen


Inclusion Criteria:



- Stage II-IV squamous cell carcinoma of the oral cavity, oropharynx, larynx or
hypopharynx, planned for curative resection.

- Age >18 years.

- Written informed consent.

Exclusion Criteria:

- Pregnancy.

- Prior treatment for this tumor

- Women breast feeding

Type of Study:

Observational

Study Design:

Observational Model: Cohort, Time Perspective: Prospective

Outcome Measure:

To validate 18F-MISO-PET for detection of tumor hypoxia and 18F-FLT-PET for detection of tumor cell proliferation by immunohistochemical assessment of hypoxia and proliferation in head and neck cancer resection specimen.

Outcome Time Frame:

1 month

Safety Issue:

No

Principal Investigator

Johannes HA Kaanders, PhD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Radboud University

Authority:

Netherlands: The Central Committee on Research Involving Human Subjects (CCMO)

Study ID:

100

NCT ID:

NCT00159978

Start Date:

July 2005

Completion Date:

December 2013

Related Keywords:

  • Head and Neck Neoplasms
  • head and neck cancer
  • hypoxia
  • tumor cell proliferation
  • PET
  • Neoplasms
  • Head and Neck Neoplasms

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