Metformin Treatment Before IVF / ICSI in Non-obese Women With Polycystic Ovarian Syndrome
PCOS is an hormonal disease including hyperandrogenism, oligo-or anovulation and/or
polycystic ovaries by ultrasound. PCOS women often suffer insulin resistance or even
diabetes risk as well as a full blown metabolic disease.
These women often suffer infertility due to their lack of regular ovulations. Metformin is a
well known anti-diabetic drug, and in some PCOS women metformin might decrease the
hyperandrogenism, improve insulin resistance and give more regular ovulations. Thereby
increase chance of pregnancy. Our hypothesis is that metformin will increase clinical
pregnancy rates both spontaneously and following IVF/ICSI.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment
To investigate whether four months of Metformin treatment before IVF (in-vitro-fertilisation) or ICSI (intra-cytoplasmic sperm injection) will increase clinical pregnancy rate in normal weight PCOS-women
Vaginal ultrasound in pregnancy week 7
Sven Carlsen, MD,PhD
St Olavs Hospital- Endocrinological section
Norway: Norwegian Medicines Agency
MET-AR study -PCOS 5