Liver Transplantation in Patients With Hepatitis C Virus (HCV) and Human Immunodeficiency Virus (HIV) Coinfection ANRS HC08 Thevic
Until recently, HIV infection was considered as a contraindication for liver
transplantation. A dramatic improvement in survival of HIV patients have been observed
since the advent of new antiviral treatments against HIV including antiproteases. However an
important proportion of patients with HCV-HIV coinfection are suffering from
life-threatening liver disease due to HCV infection. Liver transplantation may be considered
in this particular group of patients.
The ideal timing for the indication of liver transplantation during HIV disease and during
the course of HCV liver disease needs to be defined. Liver transplantation in this
particular group of patients raised several questions : a) the role of HIV infection on
prevalence and severity of HCV recurrence after transplantation ; b) the role of liver
transplantation and immunosuppression on HIV disease ; c) drug interactions between
immunosuppressive agents and antiproteases ; d) immunological follow-up and quality of life
of these patients.
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Feasibility of liver transplantation in patients with HCV-HIV coinfection: survival at one and two years.
Didier Samuel, MD
Hopital Paul Brousse Villejuif France
France: Afssaps - Agence française de sécurité sanitaire des produits de santé (Saint-Denis)
ANRS HC08 THEVIC