Inclusion Criteria:

- Histologically confirmed diagnosis of mantle cell Non-Hodgkin's Lymphoma with
characteristic immunophenotypic profiles: CD5(+),CD23(-), CD19(+) or CD20(+), cyclin
D1(+), and CD10(-)

- Patient has persistent / recurrent disease after standard chemotherapy

- Patient has not received either standard or investigational drugs within the last 3
weeks

- Available frozen tumor tissue obtained since completion of last prior therapy
(rebiopsy if needed)

- Patient has measurable disease as defined by a tumor mass > 1.5 cm in one dimension

- Age > 18 years

- Absolute granulocyte count > 1000 cells/mm3

- Platelet count > 50,000 cells/mm3

- Creatinine < 2.0 x ULN

- Total bilirubin < 2.0 x ULN

- Patient has KPS > 50%

- Patient agrees to use birth control if of reproductive potential

Exclusion Criteria:

- Known central nervous system (CNS) involvement by lymphoma

- Known HIV disease

- Known peripheral neuropathy > grade 2

- Patient is pregnant or nursing

- Patient has had major surgery within the last 3 weeks

- Patient is receiving other investigational drugs