Inclusion Criteria

All patients must have a histologic diagnosis of adenocarcinoma of the prostate with
evidence of metastases on bone or CT scan. Patients with regional metastases to pelvic
lymph nodes (D1 disease) as their only site of metastases will be excluded from this
study.

Patients on androgen suppression therapy at the time of registration must have received
less than seven months of therapy (excluding any neoadjuvant hormonal therapy) and must
have a decreasing or stable PSA level.

Patients may not be undergoing concurrent chemotherapy, biologic therapy, or radiation
therapy. Prior to radiation therapy must have completed more than 4 weeks prior to
registration.

Patients may not have received prior cytotoxic chemotherapy.

Patients may not have evidence of brain metastases or untreated spinal cord compression.