Outcome of Palliative Management of Malignant Large Bowel Obstruction With Colorectal Stents or Surgery
Large bowel obstruction is a common presentation among cancer patients, including those with
non-colorectal malignancies. This study will evaluate patients with malignant large bowel
obstruction who undergo palliative treatment with minimally invasive surgical diversion or
endoscopic colorectal stent placement, in terms quality of life, symptom relief from bowel
obstruction, and treatment-related complications. Assessments in changes in quality of life
and symptom relief over time for each group will be done.
Traditionally malignant bowel obstruction is treated with surgery. In the last decade,
creation of an ostomy can be completed with minimally invasive surgery, which reduces
morbidity, mortality, and recovery time.wishes.
In the last several years, endoscopically inserted colorectal stents have emerged as an
option for palliative treatment. This involves a simple procedure, often completed on an
outpatient basis. This allows the intestinal lumen to remain open without the need for
- Primary Objective: is to compare the effect on quality of life of minimally invasive
surgical bowel diversion and endoscopic stent placement in the treatment of malignant
large bowel obstruction.
- Secondary Objectives: are to evaluate the symptom response (including abdominal pain,
distention, bowel frequency and consistency, and nausea and emesis) and complication
rate of treatment of malignant large bowel obstruction with endoscopic stent placement
or minimally invasive surgical bowel diversion.
Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Open Label
Primary objective: compare the effect on quality of life of minimally invasive surgical bowel diversion and endoscopic stent placement in the treatment of malignant large bowel obstruction.
Hans Gerdes, M.D.
Memorial Sloan-Kettering Cancer Center
United States: Institutional Review Board
|Memorial Sloan-Kettering Cancer Center||New York, New York 10021|