Longitudinal Enumeration of Circulating Tumor Cells in Patients With Metastatic Colorectal Carcinomas
Inclusion Criteria:
- Measurable metastatic carcinoma of the colon or rectum.
- 1st or 2nd line chemotherapy (3rd line acceptable with epidermal growth factor
receptor [EGFR] targeted therapy)
- Chest/abdomen/pelvis scans every 6-12 weeks
- ECOG 0-2
- Hemoglobin (Hgb) > or = 8g/dl within 7 days prior to enrollment
- Age > or = to 18 years of age
Exclusion Criteria:
- Cumulative weekly blood draws exceeding 150mL/week
- Brain metastasis
- Prior history of other carcinoma within the last 5 years, except ductal carcinoma in
situ (DCIS), non-invasive cervical cancer or non-melanoma skin cancer
- Surgery within 14 days of the initial blood draw, excluding surgical placement of a
central venous device