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The Quality of Life of Adult Survivors Who Received a Marrow Transplant as a Child


Phase 2
18 Years
N/A
Not Enrolling
Both
Leukemia, Lymphoma, Myelodysplastic Syndromes, Quality of Life

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Trial Information

The Quality of Life of Adult Survivors Who Received a Marrow Transplant as a Child


OBJECTIVES:

- Determine the extent to which adult cancer survivors who have undergone prior bone
marrow or peripheral blood stem cell transplantation for a pediatric hematologic
malignancy require ongoing health care and whether these needs change with increasing
time after transplantation.

- Correlate physical capabilities, body image, physical limitations, including sexuality
issues which alter or influence lifestyle, with time after transplantation in these
patients.

- Determine whether cognitive abilities relative to memory and neurobehavioral ratings
change with increasing time after transplantation in these patients.

- Correlate social and relationship abilities with length of time after transplantation
in these patients.

OUTLINE: Patients and siblings complete a self-report quality of life questionnaire,
including outcome assessments of neuroendocrine function, cognitive abilities, physical
capability, and psychosocial behavior.

PROJECTED ACCRUAL: Approximately 750 patients (375 adult cancer survivors [case group] and
375 siblings [control group]) will be accrued for this study within 7 years.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Case group

- Previously treated with an allogeneic, unrelated, syngeneic, or autologous bone
marrow or peripheral blood stem cell transplantation for a hematologic
malignancy ≥ 5 years ago while enrolled on 1 of the following protocols:

- FHCRC-160.06

- FHCRC-179.07T

- FHCRC-446.03T

- FHCRC-661.04

- FHCRC-697.00

- FHCRC-796.00

- FHCRC-843.00

- Disease-free survivor

- Under 18 years of age at time of transplantation

- Any prior preparative regimen allowed

- Control group

- Sex-matched sibling within 5 years of patient's age*

- No chronic illnesses (e.g., cancer, diabetes, or asthma) that require medication

- No allergies that limit physical activity NOTE: *If such a sibling is not
available, but another sibling is available, then that sibling would be asked to
nominate a friend or relative of the same gender as the patient who is also
within 5 years of the patient's age; the patient must consent in order for the
control subject to participate

PATIENT CHARACTERISTICS:

Age

- See Disease Characteristics

- 18 and over

Performance status

- Not specified

Life expectancy

- Not specified

Hematopoietic

- Not specified

Hepatic

- Not specified

Renal

- Not specified

Other

- Must be able to speak, read, and write English

PRIOR CONCURRENT THERAPY:

Biologic therapy

- See Disease Characteristics

Chemotherapy

- Not specified

Endocrine therapy

- Not specified

Radiotherapy

- Not specified

Surgery

- Not specified

Type of Study:

Observational

Study Design:

N/A

Outcome Measure:

Neuroendocrine status of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18

Principal Investigator

Jean E. Sanders, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Fred Hutchinson Cancer Research Center

Authority:

United States: Federal Government

Study ID:

1098.00

NCT ID:

NCT00126477

Start Date:

March 1996

Completion Date:

March 2010

Related Keywords:

  • Leukemia
  • Lymphoma
  • Myelodysplastic Syndromes
  • Quality of Life
  • quality of life
  • de novo myelodysplastic syndromes
  • previously treated myelodysplastic syndromes
  • secondary myelodysplastic syndromes
  • juvenile myelomonocytic leukemia
  • childhood Hodgkin lymphoma
  • childhood lymphoblastic lymphoma
  • childhood large cell lymphoma
  • childhood small noncleaved cell lymphoma
  • childhood acute lymphoblastic leukemia in remission
  • childhood acute myeloid leukemia in remission
  • childhood chronic myelogenous leukemia
  • Leukemia
  • Lymphoma
  • Myelodysplastic Syndromes
  • Preleukemia

Name

Location

Fred Hutchinson Cancer Research CenterSeattle, Washington  98109