The Quality of Life of Adult Survivors Who Received a Marrow Transplant as a Child
18 Years
N/A
Both
Leukemia, Lymphoma, Myelodysplastic Syndromes, Quality of Life
Trial Information
The Quality of Life of Adult Survivors Who Received a Marrow Transplant as a Child
OBJECTIVES:
- Determine the extent to which adult cancer survivors who have undergone prior bone
marrow or peripheral blood stem cell transplantation for a pediatric hematologic
malignancy require ongoing health care and whether these needs change with increasing
time after transplantation.
- Correlate physical capabilities, body image, physical limitations, including sexuality
issues which alter or influence lifestyle, with time after transplantation in these
patients.
- Determine whether cognitive abilities relative to memory and neurobehavioral ratings
change with increasing time after transplantation in these patients.
- Correlate social and relationship abilities with length of time after transplantation
in these patients.
OUTLINE: Patients and siblings complete a self-report quality of life questionnaire,
including outcome assessments of neuroendocrine function, cognitive abilities, physical
capability, and psychosocial behavior.
PROJECTED ACCRUAL: Approximately 750 patients (375 adult cancer survivors [case group] and
375 siblings [control group]) will be accrued for this study within 7 years.
Inclusion Criteria
DISEASE CHARACTERISTICS:
- Case group
- Previously treated with an allogeneic, unrelated, syngeneic, or autologous bone
marrow or peripheral blood stem cell transplantation for a hematologic
malignancy ≥ 5 years ago while enrolled on 1 of the following protocols:
- FHCRC-160.06
- FHCRC-179.07T
- FHCRC-446.03T
- FHCRC-661.04
- FHCRC-697.00
- FHCRC-796.00
- FHCRC-843.00
- Disease-free survivor
- Under 18 years of age at time of transplantation
- Any prior preparative regimen allowed
- Control group
- Sex-matched sibling within 5 years of patient's age*
- No chronic illnesses (e.g., cancer, diabetes, or asthma) that require medication
- No allergies that limit physical activity NOTE: *If such a sibling is not
available, but another sibling is available, then that sibling would be asked to
nominate a friend or relative of the same gender as the patient who is also
within 5 years of the patient's age; the patient must consent in order for the
control subject to participate
PATIENT CHARACTERISTICS:
Age
- See Disease Characteristics
- 18 and over
Performance status
- Not specified
Life expectancy
- Not specified
Hematopoietic
- Not specified
Hepatic
- Not specified
Renal
- Not specified
Other
- Must be able to speak, read, and write English
PRIOR CONCURRENT THERAPY:
Biologic therapy
- See Disease Characteristics
Chemotherapy
- Not specified
Endocrine therapy
- Not specified
Radiotherapy
- Not specified
Surgery
- Not specified
Type of Study:
Observational
Study Design:
N/A
Outcome Measure:
Neuroendocrine status of disease-free childhood transplant patients at 5 years after transplant and ≥ age 18
Principal Investigator
Jean E. Sanders, MD
Investigator Role:
Principal Investigator
Investigator Affiliation:
Fred Hutchinson Cancer Research Center
Authority:
United States: Federal Government
Study ID:
1098.00
NCT ID:
NCT00126477
Start Date:
March 1996
Completion Date:
March 2010
Related Keywords:
- Leukemia
- Lymphoma
- Myelodysplastic Syndromes
- Quality of Life
- quality of life
- de novo myelodysplastic syndromes
- previously treated myelodysplastic syndromes
- secondary myelodysplastic syndromes
- juvenile myelomonocytic leukemia
- childhood Hodgkin lymphoma
- childhood lymphoblastic lymphoma
- childhood large cell lymphoma
- childhood small noncleaved cell lymphoma
- childhood acute lymphoblastic leukemia in remission
- childhood acute myeloid leukemia in remission
- childhood chronic myelogenous leukemia
- Leukemia
- Lymphoma
- Myelodysplastic Syndromes
- Preleukemia
Name | Location |
|---|---|
| Fred Hutchinson Cancer Research Center | Seattle, Washington 98109 |
