Levonorgestrel Containing Intrauterine Device in the Treatment of Endometrial Hyperplasia Without Atypia
Endometrial hyperplasia without atypia is a condition usually caused by excessive
stimulation of the uterine lining (endometrium) by estrogens, and may cause irregular
bleeding as a presenting symptom, but rarely may progress to endometrial cancer, which makes
treatment important. The only treatment approved so far is medroxyprogesterone acetate
tablets (progesterone), also known as Provera.
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Treatment
Pathologic examination of the specimens obtained by endometrial biopsy to determine the regression of endometrial hyperplasia without atypia compared to Provera
Richard Legro, M.D.
Penn State University College of Medicine
United States: Institutional Review Board