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An Open-Labeled Non-Randomized Phase I Study of 17-N-allylamino-17-demethoxy Geldanamycin (17AAG) Administered With Irinotecan (CPT-11) in Patients With Advanced Solid Tumors

Phase 1
18 Years
Not Enrolling
Unspecified Adult Solid Tumor, Protocol Specific

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Trial Information

An Open-Labeled Non-Randomized Phase I Study of 17-N-allylamino-17-demethoxy Geldanamycin (17AAG) Administered With Irinotecan (CPT-11) in Patients With Advanced Solid Tumors


I. To determine the maximum tolerated dose (MTD) of combined 17AAG and irinotecan given
weekly for two weeks in a 21-day cycle that can be used for future phase II studies.


I. To explore the effects of the combination on the expression of Hsp90 client proteins in
peripheral mononuclear cells and tumor tissues. Tumor biopsies will be performed before and
after 17AAG treatment in 12 patients at the MTD ("Expanded Cohort") only.

II. To investigate the clinical pharmacokinetics of intravenous 17AAG, irinotecan, and their
metabolites, in this combination.

III. To obtain preliminary data on the therapeutic activity of 17AAG in combination with
irinotecan in patients with advanced solid tumors.

IV. To obtain preliminary result in the relationship between tumor response and p53-status.

OUTLINE: This is an open-label, non-randomized, dose-escalation study.

Patients receive irinotecan IV over 30 minutes followed by
17-N-allylamino-17-demethoxygeldanamycin (17-AAG)* IV over 2 hours on days 1 and 8.
Treatment repeats every 21 days for at least 2 courses in the absence of disease progression
or unacceptable toxicity. Patients achieving stable or improved disease after course 2 may
receive additional courses of treatment.

NOTE: *17-AAG is administered on days 2 and 8 during course 2 for patients treated at
non-maximum tolerated doses (MTD) (dose-escalation portion) and on day 8 only during course
1 for patients treated at the MTD (expanded cohort).Cohorts of 3-6 patients receive
escalating doses of 17-AAG and irinotecan until the MTD is determined. The MTD is defined as
the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting
toxicity. An additional 12 patients are treated at the MTD.

Inclusion Criteria:

- Histologically confirmed solid tumor, excluding primary CNS tumors

- Locally advanced or metastatic disease that is refractory to standard therapy OR
for which no standard therapy exists

- Tumor assessible for biopsy by Tru-cut^®, CT guidance, or endoscopy (for patients
treated at the maximum tolerated dose [expanded cohort only])

- Pleural effusions or abdominal ascites are not considered biopsy-accessible

- No known new CNS metastases that have not been previously treated

- Performance status - Karnofsky 60-100%

- WBC ≥ 3,000/mm^3

- Absolute neutrophil count ≥ 1,500/mm^3

- Platelet count ≥ 100,000/mm^3

- Bilirubin ≤ 1.5 mg/dL

- AST and ALT ≤ 3 times upper limit of normal (ULN) (5 times ULN if liver metastases
are present)

- Creatinine ≤ 1.5 mg/dL

- No history of cardiac arrhythmias

- No myocardial infarction within the past 12 months

- No active ischemic heart disease within the past 12 months

- No New York Heart Association class III-IV congestive heart failure or LVEF < 40% by

- No history of uncontrolled cardiac dysrhythmia or dysrhthmias requiring medication

- No history of serious ventricular arrhythmia (i.e., ventricular tachycardia or
ventricular fibrillation ≥ 3 beats in a row)

- No congenital long QT syndrome

- No left bundle branch block

- QTc < 450 msec (for male patients)

- QTc < 470 msec (for female patients)

- Not pregnant

- No nursing during and for 2 months after study participation

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 2 months after
study participation

- No serious or uncontrolled infection

- No history of serious allergic reaction to eggs
or egg products

- No other medical condition that would preclude study participation

- At least 3 weeks since prior immunotherapy

- No concurrent prophylactic filgrastim (G-CSF) or sargramostim (GM-CSF)

- At least 3 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)

- Prior irinotecan allowed

- No prior 17-N-allylamino-17-demethoxygeldanamycin (17-AAG)

- At least 2 weeks since prior non-myelosuppressive chemotherapy (at the discretion of
the principal investigator)

- At least 3 weeks since prior radiotherapy

- No prior radiotherapy field that included the heart (e.g., mantle)

- Recovered from all prior therapy

- At least 3 weeks since prior anticancer investigational therapeutic drugs

- More than 7 days since prior and no concurrent inducers, inhibitors, or modifiers of
CYP3A4, including any of the following:

- Fluconazole

- Itraconazole

- Ketoconazole

- Azithromycin

- Clarithromycin

- Erythromycin

- Troleandomycin

- Nifedipine

- Verapamil

- Diltiazem

- Nefazodone

- Cyclosporine

- Grapefruit juice (> 1 quart/day)

- Indinavir

- Nelfinavir

- Ritonavir

- Saquinavir

- Carbamazepine

- Phenobarbital

- Phenytoin

- Rifampin

- Hydrastis canadensis (goldenseal)

- Hypericum perforatum (St. John's wort)

- Uncaria tomentosa (cat's claw)

- Echinacea angustifolia root

- Trifolium pratense (wild cherry)

- Matricaria chamomila (chamomile)

- Glycyrrhiza glabra (licorice)

- Dillapiol

- Hypericin

- Naringenin

- No concurrent medications that would prolong QTc

- No concurrent vitamins, antioxidants, herbal preparations, or supplements

- Concurrent single daily multivitamin allowed

- No other concurrent anticancer therapy

- No concurrent combination antiretroviral therapy for HIV-positive patients

- No other concurrent investigational medications

Type of Study:


Study Design:

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Maximum tolerated dose determined by dose-limiting toxicities

Outcome Time Frame:

21 days

Safety Issue:


Principal Investigator

Archie Tse

Investigator Role:

Principal Investigator

Investigator Affiliation:

Memorial Sloan-Kettering Cancer Center


United States: Food and Drug Administration

Study ID:




Start Date:

May 2005

Completion Date:

Related Keywords:

  • Unspecified Adult Solid Tumor, Protocol Specific
  • Neoplasms



Memorial Sloan Kettering Cancer Center New York, New York  10021