A Phase III Trial of External Beam of Radiotherapy +/- Total Androgen Suppression for High Risk Clinically Organ-Confined Prostate Cancer
This was a randomized study comparing external beam radiation therapy with total androgen
ablation for 6 months with radiation therapy alone. Drugs were given 2 months prior, 2
months during, and 2 months after radiation therapy. Eulexin and Lupron or Zoladex was used
in this study.
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
To determine if the 2 year freedom from PSA failure is increased in patients receiving total androgen suppression and radiation therapy compared to those patients receiving radiation therapy alone.
Anthony V D'Amico, M.D. Ph.D.
Dana-Farber Cancer Institute
United States: Institutional Review Board
|Dana-Farber Cancer Institute||Boston, Massachusetts 02115|