Inclusion Criteria:

Subjects must satisfy the following criteria to be enrolled in the study:

- Male or female

- Not a candidate for HDT/SCT due to: age - subject is 65 years or older or in subjects
less than 65 years of age - presence of important comorbid condition(s) likely to
have a negative impact on tolerability of HDT/SCT.

- Symptomatic multiple myeloma or asymptomatic multiple myeloma with related organ or
tissue damage. Asymptomatic multiple myeloma-related organ or tissue damage can
include presence of asymptomatic lytic bone lesion or plasmacytoma, or presence of
anemia, renal function impairment, or hypercalcemia, as long as the criteria for
pre-treatment clinical laboratory values indicated below are met.

- Presence of measurable disease, defined as:

- For secretory multiple myeloma, measurable disease is defined as any
quantifiable serum monoclonal protein value.

- For oligosecretory or nonsecretory multiple myeloma, measurable disease is
defined by the presence of measurable soft tissue or organ (not bone)
plasmacytomas as determined by clinical examination or applicable radiographs.

- Karnofsky performance status score of equal or greater then 60%.

- Willing and able to complete the PRO instruments

- Agrees to use an acceptable barrier method for contraception for the duration of the
study (for male subjects); If female subjects are still having menstrual periods and
are not surgically sterile, they must be practicing an effective method of birth
control before entry, and throughout the study, and have a negative serum B-HCG
pregnancy test at screening.

- Have pretreatment clinical laboratory values meeting the criteria as described in the
protocol within 14 days before randomization.

- Subjects (or their legally acceptable representatives) must have signed an informed
consent document indicating that they understand the purpose of and procedures
required for the study and are willing to participate in the study.

Exclusion Criteria:

Potential subjects who meet any of the following criteria will be excluded from
participating in the study:

- Diagnosis of smoldering multiple myeloma or monoclonal gammopathy of undetermined
significance (MGUS, hypercalcemia, and renal insufficiency related to the monoclonal
protein; and (if determined) proportion of plasma cells in the bone marrow of 10% or
less.

- Diagnosis of Waldenström's disease or other conditions in which IgM M protein is
present in the absence of a clonal plasma cell infiltration with lytic bone lesions

- Prior or current systemic therapy for multiple myeloma including steroids (with the
exception of emergency use of a short course [maximum of 4 days] of steroids before
randomization or of prior or current use of bisphosphonates)

- Radiation therapy within 30 days before randomization

- Plasmapheresis within 30 days before randomization

- Major surgery within 30 days before randomization (kyphoplasty is not considered
major surgery)

- History of allergic reaction attributable to compounds containing boron or mannitol

- Peripheral neuropathy or neuropathic pain Grade 2 or higher.

- Uncontrolled or severe cardiovascular disease, including myocardial infarction,
within 6 months of enrollment, uncontrolled angina, clinically significant
pericardial disease, or cardiac amyloidosis

- Other malignancy within the past 5 years. Exceptions if treated and not active
include the following: basal cell or nonmetastatic squamous cell carcinoma of the
skin, cervical carcinoma in situ or International Federation of Gynecology and
Obstetrics (FIGO) Stage 1 carcinoma of the cervix

- Concurrent medical condition or disease (e.g., active systemic infection,
uncontrolled diabetes) that is likely to interfere with study procedures or results,
or that, in the opinion of the investigator would constitute a hazard for
participating in this study

- Use of any investigational drugs within 30 days before randomization

- Employees of the investigator or study center, with direct involvement in the
proposed study or other studies under the direction of that investigator or study
center, or family members of the employees or the investigator.