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The Effects of Microdermabrasion on Collagen and Elastin Biosynthesis

18 Years
Not Enrolling
Healthy Skin, Skin Wrinkling

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Trial Information

The Effects of Microdermabrasion on Collagen and Elastin Biosynthesis

Microdermabrasion is rapidly becoming one of the most popular cosmetic procedures performed
by dermatologists and plastic surgeons. Microdermabrasion is a process that uses a
high-pressure stream of aluminum oxide crystals and negative pressure to superficially peel
the upper layer of the skin. Its purported benefits include improvement of photoaged skin,
acne, and facial scarring.

The appeal of microdermabrasion is its effectiveness, simplicity, low patient and operator
risk, and rapid recovery. Clinically, studies have illustrated beneficial effects on
photodamaged skin.

Histologically, microdermabrasion has reproducible effects on the epidermis and dermis.
Studies have shown a consistent increase in epidermal thickness as well as changes in the
elastin content of the dermis while changes in collagen content have not been observed.

The reported clinical and histologic changes seen in previous studies suggest that
alterations in the dermis precipitated by epidermal injury may be responsible for the
beneficial effects of microdermabrasion on photoaging and scarring. In fact, others have
reported that skin fibroblasts under tension may increase collagen synthesis.

Disruption of the epidermal barrier initiates a repair process that restores barrier
function within hours to days, depending on the severity of the damage. This repair process
involves increased synthesis of barrier lipids, followed by formation of new corneocytes.
Elevated lipid synthesis largely occurs as a result of increased gene expression of the
major enzymes responsible for lipid biosynthesis.

In this study, subjects will be assigned to one of two treatment groups. Patients in the
first group will have their hip/buttock or forearm treated with the microdermabrasion
machine. There may be only one treatment or as many as 6 on the same area, spaced up to two
weeks apart. The treated area will be on either the right or left buttock and/or forearm
and/or underarm. An area of approximately 10x10 cm (4x4 inches) will be treated. Skin
biopsies will be performed on up to nine different times, up to six months following
dermabrasion, on treated and/or untreated skin from the buttocks, forearm and/or underarm.
Therefore, a total of (up to) nine biopsies will be taken from subjects in this group. The
biopsies will be 4 mm or smaller in size, or about the size of a pencil eraser. Subjects
can expect to make six visits to the hospital over a 3-4 week period of time.

Subjects assigned to the second group will have their face treated with microdermabrasion at
a weekly to biweekly interval for a total of six treatments. One pair of biopsies will be
taken prior to the first treatment, and the 2nd and 3rd pair will be taken on two different
occasions no later than 3 months following the final treatment. Thus, the maximum number of
biopsies in group II is six. The biopsies will be 2mm punch, "cookie-cutter", biopsies and
will be taken from in front of the ear. Subjects can expect to make 8-10 visits to the
hospital over a 2-3 month period of time.

Inclusion Criteria:

- Ages 18 or older

- Patients must be available for follow up visits for biopsies to comply with the
requirements of the protocol.

- Patients must sign and understand the informed consent prior to participation in the

- You must live within a reasonable driving distance of Ann Arbor, Michigan, and/or be
able to attend all of the scheduled appointments during the study

Exclusion Criteria:

- Oral retinoid (vitamin-A like drugs) use within one year of entry into the study

- Topical retinoid use within 3 months of the study

- Patients with a history of excessive scarring

- Patients with significant medical history or concurrent illness which investigators
feel is not safe for study participation

- Patients who have had any type of facial rejuvenation procedure or treatment (such as
Botox injections, collagen implants, or chemical peels) within the past six months

- Non-compliant patients

- Pregnant women

Type of Study:


Study Design:

Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Observing changes over time with respect to the following biochemical endpoints: Procollagen I and III, matrix metalloproteinases (MMPs 1, 3, and 9), and several cytokines including Interleukins and Tumor Necrosis Factor.

Outcome Time Frame:

Group I: 1-4 weeks; Group II: 1-3 months

Safety Issue:


Principal Investigator

John J Voorhees, MD

Investigator Role:

Study Chair

Investigator Affiliation:

University of Michigan


United States: Institutional Review Board

Study ID:

Derm 486



Start Date:

June 2002

Completion Date:

July 2009

Related Keywords:

  • Healthy Skin
  • Skin Wrinkling
  • microdermabrasion
  • skin
  • wrinkles
  • collagen
  • photoaging
  • wrinkled skin