Trial Information

Post-Operative Pain Relief Following Insertion of Radioactive Plaque for Choroidal Melanoma: Randomised Control Trial of Tramadol Vs Ibuprofen: A Pilot Study

Patients with choroidal melanomas who are offered ruthenium plaque radiotherapy have their
plaque sutured to the sclera under general anaesthesia. The plaque is removed in a few days
after delivering the required radioactive dosage to the tumour. While the plaque is in
situ, patients require analgesia. The management of post-operative pain is generally not
considered a high priority, more importance being given to the regression of the melanoma.

This is indicated by the lack of any study addressing this aspect of care. The failure of
patients in general, to complain, may perhaps be due to them having accepted that some
degree of pain following 'major surgery for a malignant ocular condition' is the norm.

As per current protocol, ibuprofen is being prescribed, unless contraindicated. Although
many are comfortable, others request additional analgesics. Most opioid analgesics provide
better pain relief but are associated with nausea, vomiting, constipation and respiratory
depression.

Tramadol is an opioid analgesic that is reported to have less of the above mentioned side
affects.

Comparisons: To compare the analgesic effect of oral tramadol versus ibuprofen in such
patients.