Highly active antiretroviral therapy (HAART) has altered the natural history of HIV disease
A significant minority of HIV-infected children has evidence of ongoing CNS disease.
Specific markers for CNS disease, factors predictive of risk for neurological decline, and
pathophysiologic mechanisms have not yet been identified in HIV-infected children.
To explore the clinical features (neurological and psychiatric exams, neuropsychological
evaluation, and neuroimaging), viral and neuroinflammatory factors, anatomic changes (brain
MRI) and patterns of brain metabolites (1H-MRS) associated with HIV-related CNS disease in
HIV-infected children in the HAART era.
HIV disease acquired in the first decade of life.
Evidence of CNS disease (classification of encephalopathy or CNS compromise or diagnosis of
ADHD, bipolar disease, major depression, or psychosis).
Serial neurologic and psychiatric examinations, neuropsychologic test, neuroimaging, and CSF
sampling will be performed once a year for a total of 3 evaluations.
Rohan Hazra, M.D.
National Cancer Institute (NCI)
United States: Federal Government
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Bethesda, Maryland 20892|