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A Phase II Study of VELCADE With Rituximab in Subjects With Relapsed or Refractory Indolent B-Cell Lymphoma


Phase 2
18 Years
N/A
Not Enrolling
Both
Lymphoma

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Trial Information

A Phase II Study of VELCADE With Rituximab in Subjects With Relapsed or Refractory Indolent B-Cell Lymphoma


OBJECTIVES:

Primary

- Determine the response rate (complete response [CR], CR-unconfirmed [CRu], and partial
response [PR]) in patients with relapsed or refractory indolent B-cell non-Hodgkin's
lymphoma treated with bortezomib and rituximab.

Secondary

- Determine the response rate (CR, CRu, and PR) at the first disease response evaluation
in patients treated with this regimen.

- Determine the overall CR rate (CR and CRu) in patients treated with this regimen.

- Determine the time to progression in patients treated with this regimen.

- Determine the duration of response in patients treated with this regimen.

- Determine the time to best response in patients treated with this regimen.

- Determine the safety and tolerability of this regimen in these patients.

OUTLINE: This is a randomized, open-label, multicenter study. Patients are stratified
according to participating center, Karnofsky performance status (< 70% vs ≥ 70%), lactic
dehydrogenase level (normal vs > upper limit of normal), age (18 to 60 years vs > 60 years),
and lymphoma subtype (follicular vs marginal zone). Patients are randomized to 1 of 2
treatment arms.

- Arm I: Patients receive bortezomib IV over 3-5 seconds on days 1, 4, 8, and 11.
Patients also receive rituximab IV on days 1, 8, and 15 of course 1 only and on day 1
of course 2 only. Treatment with repeats every 21 days for up to 5 courses in the
absence of disease progression or unacceptable toxicity.

- Arm II: Patients receive bortezomib IV over 3-5 seconds on days 1, 8, 15 and 22.
Patients also receive rituximab IV on days 1, 8, 15, and 22 of course 1 only. Treatment
repeats every 35 days for up to 3 courses in the absence of disease progression or
unacceptable toxicity.

Patients in either arm may crossover to the other arm if treatment is found to be
ineffective.

Patients are followed at 30 days and then every 12 weeks thereafter.

PROJECTED ACCRUAL: A total of 24-66 patients (12-33 per treatment arm) will be accrued for
this study within 1 year.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Diagnosis of indolent B-cell non-Hodgkin's lymphoma of 1 of the following subtypes:

- Follicular (grade 1, 2, or 3)

- Marginal zone (extranodal, nodal, or splenic)

- CD20-positive disease

- Relapsed or progressive disease after prior anti-neoplastic therapy, as indicated by
1 of the following:

- New lesions

- Objective evidence of progression of existing lesions

- Complete response ≥ 6 months in duration after prior rituximab therapy* NOTE: *For
patients who were previously treated with a regimen that included rituximab

- At least 1 measurable lymph node mass > 1.5 cm in 2 perpendicular dimensions that has
not been irradiated OR that has progressed since prior radiotherapy

- No active CNS lymphoma

PATIENT CHARACTERISTICS:

Age

- 18 and over

Performance status

- Karnofsky 50-100% OR

- ECOG 0-2

Life expectancy

- Not specified

Hematopoietic

- Absolute neutrophil count ≥ 1,000/mm^3

- Platelet count ≥ 50,000/mm^3

Hepatic

- AST and ALT ≤ 3 times upper limit of normal (ULN)

- Bilirubin ≤ 2 times ULN

Renal

- Creatinine ≤ 2 mg/dL OR

- Creatinine clearance ≥ 30 mL/min

Immunologic

- No known anaphylaxis or immunoglobulin E-mediated hypersensitivity to murine proteins
or to any component of rituximab, including polysorbate 80 and sodium citrate
dihydrate

- No active systemic infection requiring treatment

- No history of allergic reaction attributable to compounds containing boron or
mannitol

Other

- No peripheral neuropathy or neuropathic pain ≥ grade 2

- No other malignancy within the past 5 years except completely resected basal cell or
squamous cell skin cancer or an in situ malignancy

- Previously diagnosed prostate cancer allowed provided the following criteria are
met:

- T1-2a, N0, M0 disease AND Gleason score ≤ 7 AND prostate specific antigen
(PSA) ≤ 10 ng/mL before initial therapy

- Treated with definitive curative therapy (i.e., prostatectomy or
radiotherapy) within the past 2 years

- No clinical evidence of prostate cancer AND undetectable PSA (for
prostatectomy patients) or PSA < 1 ng/mL (for patients who did not undergo
prostatectomy)

- No serious medical or psychiatric illness that would preclude study participation

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY:

Biologic therapy

- See Disease Characteristics

- More than 10 weeks since prior radioimmunoconjugates or toxin immunoconjugates (e.g.,
ibritumomab tiuxetan or iodine I 131 tositumomab)

- More than 4 weeks since prior rituximab, alemtuzumab, or other unconjugated
therapeutic antibody

- No concurrent prophylactic bone marrow growth factors (e.g., filgrastim [G-CSF],
sargramostim [GM-CSF], or epoetin alfa) during course 1 of study therapy

Chemotherapy

- More than 6 weeks since prior nitrosoureas

- No concurrent cisplatin

Endocrine therapy

- No concurrent corticosteroids (e.g., dexamethasone) except prednisone ≤ 15 mg/day or
equivalent for adrenal insufficiency

Radiotherapy

- See Disease Characteristics

- See Biologic therapy

- More than 3 weeks since prior radiotherapy

- No concurrent radiotherapy

Surgery

- More than 2 weeks since prior major surgery

Other

- Recovered from all prior therapy

- No prior bortezomib

- More than 3 weeks since prior antineoplastic therapy

- More than 3 weeks since prior experimental therapy

- No other concurrent antineoplastic therapy

- No other concurrent investigational agents

- Concurrent participation in a non-treatment study allowed provided it does not
interfere with participation in this study

Type of Study:

Interventional

Study Design:

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Outcome Measure:

Response rate (complete response [CR], CR-unconfirmed [CRu], and partial response [PR])

Outcome Time Frame:

12 weeks

Safety Issue:

No

Principal Investigator

Sven De Vos, MD

Investigator Role:

Principal Investigator

Investigator Affiliation:

Jonsson Comprehensive Cancer Center

Authority:

United States: Food and Drug Administration

Study ID:

CDR0000390235

NCT ID:

NCT00093769

Start Date:

August 2004

Completion Date:

Related Keywords:

  • Lymphoma
  • recurrent grade 1 follicular lymphoma
  • recurrent grade 2 follicular lymphoma
  • recurrent grade 3 follicular lymphoma
  • extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue
  • nodal marginal zone B-cell lymphoma
  • recurrent marginal zone lymphoma
  • splenic marginal zone lymphoma
  • Lymphoma
  • Lymphoma, Non-Hodgkin
  • Lymphoma, B-Cell

Name

Location

Jonsson Comprehensive Cancer Center at UCLALos Angeles, California  90095-1781