Inclusion Criteria

Inclusion Criteria

- Pancreatic cancer (AJCC Stage II-IV);

- Unresectable cancer;

- Measurable disease (RECIST criteria);

- No prior therapy;

- ECOG Score 0-2

- Life expectancy greater then or equal to three months;

- Adequate hematopoietic, liver and renal function;

- Women of child-bearing potential must have negative urine/serum pregnancy test;

- Signed written informed consent;

- Subjects must be willing to be followed during the course of the
treatment/observation and follow-up.

Exclusion Criteria:

- Prior therapy for pancreatic cancer;

- Previously diagnosed brain metastases if symptomatic and requiring active therapy;

- Other cancers within the last five years, with the exception of adequately treated
cone-biopsied in-situ carcinoma of the cervix uteri or basal or squamous cell
carcinoma of the skin;

- Any serious concomitant medical or mental illness requiring intense therapy and
interfering with participation in this study

- Primary or secondary immunodeficiency, or use of corticosteroids immunosuppressive
medication;

- Women must not be pregnant or breast-feeding;

- Participation in any clinical trial involving investigational drugs within one month
from enrollment into the present study.