Inclusion Criteria

Inclusion Criteria

- A histologically confirmed diagnosis of follicular lymphoma, Grade I, II, or III
(WHO/REAL Classification) (follicular, small cleaved; follicular, mixed small-cleaved
and large-cell; or follicular large-cell lymphoma in the International Working
Formulation).

- Recurrent lymphoma after one or two qualifying therapy regimen(s).

- A performance status of at least 70% on the Karnofsky Scale.

- An absolute neutrophil count > 1500 cells/mm3 and a platelet count > 100,000
cells/mm3.

- Adequate renal function and adequate hepatic function.

- Bi-dimensionally measurable disease with at least one lesion measuring > or equal to
2.0 x 2.0 cm (i.e., > 4.0 cm2) by CT scan.

- HAMA negative.

- At least 18 years of age.

- Give written informed consent by signing an IRB/ethics committee approved informed
consent form prior to study entry.

Exclusion Criteria

- Histological transformation to diffuse,large cell lymphoma

- More than 1 course of rituximab

- Disease better treated with limited field therapy

- Involvement of >25% of the intratrabecular marrow

- Active infection

- Significant cardiac disease

- Prior ChemoRx, biological therapy, radiation Rx, or high dose systemic steroid
therapy within 8 weeks

- Prior radioimmunotherapy

- History of another malignancy

- HBsAg positivity

- CNS involvement with lymphoma

- Pregnant or nursing

- Ascites by physical exam

- Previous use of non-human monoclonal antibody therapy, known hypersensitive to murine
proteins

- Hydronephrosis

- Radiotherapy to >25% of the blood forming marrow

- Prior stem cell transplant

- Failed stem cell harvest