Evaluation of HIV-Specific Immunological and Virological Responses of HIV-1 Multiply-Exposed Seronegative Individuals
Rare individuals appear naturally resistant to overt HIV-1 infection despite repeated sexual
exposures. These individuals, referred to as exposed seronegatives (ES), represent a unique
population in which to evaluate mechanisms by which HIV-1 replication is either controlled
or aborted. The purpose of the study is to analyze HIV-specific immune responses, both
cellular and humoral, that exist in seronegative individuals who have experienced multiple
exposures to HIV by sexual contact.
This study will follow participants for 2 years. Participants will have 25 study visits
during the study. Assessments will include HIV tests, viral load measurements, CD4 counts,
pregnancy tests, and physical exams.
Observational Model: Defined Population, Observational Model: Natural History, Time Perspective: Longitudinal, Time Perspective: Prospective
Julie McElrath, MD, PhD
University of Washington
United States: Federal Government
|Fred Hutchinson Cancer Research Center / University of Washington HIV Vaccine Trials Unit||Seattle, Washington 98104|