Inclusion Criteria

Inclusion Criteria

- Current diagnosis of metastatic melanoma, where other effective therapy is not
available or has failed.

- Measurable disease. Metastatic lesions must be measurable by MRI or CT, and cutaneous
lesions by physical examination.

- Aged at least 18 years.

- Have voluntarily given written informed consent to participate in this study.

- Performance status: ECOG 0 - 2 (Karnofsky 70 -100%)

- Life expectancy of at least 3 months.

- Neutrophil count greater than 1.5 x 109/L (1,500/mm3)

- Calculated creatinine clearance, using the Cockcroft-Gault formula, greater than 60
mL/min. If just below 60 mL/min, then GFR greater than 60 mL/min as determined by
EDTA or DTPA scan.

- Platelet count at least 100 x 109/L (100,000/mm3)

- Bilirubin less than 1.5 x ULN

- AST and ALT up to 2 x ULN, except in the presence of liver metastases; up to 5 x ULN.

- Prothrombin time less than 1.5 x ULN

- APTT normal (20 - 34 sec)

Exclusion Criteria:

- History of allergy and/or hypersensitivity to anti-coagulants/thrombolytic agents,
especially heparin.

- Chemotherapy, investigational or hormonal therapy in the previous 4 weeks.

- Radiotherapy to a major bone marrow bearing area such as pelvis, femoral heads,
lumbar-sacral spine, within the previous 4 weeks. Radiotherapy to other sites within
the past 2 weeks.

- Uncontrolled infection or serious infection within the past 4 weeks.

- Clinically significant non-malignant disease.

- Known HIV infection or AIDS-related illness.

- Myocardial infarction, stroke or congestive heart failure within the past 3 months.

- Current symptomatic central nervous system involvement, or active brain or meningeal
metastases.

- Pregnancy, breast feeding, or women of childbearing potential in whom pregnancy
cannot be excluded.

- History of abuse of alcohol, drugs, or other substances.

- History of acute or chronic gastrointestinal bleeding within the last two years,
inflammatory bowel disease, any other abnormal bleeding tendency, or patients at risk
of bleeding due to open wounds or planned surgery.

- Concomitant use of aspirin (more than 100 mg/day), non-steroidal anti-inflammatory
drugs (except COX-2 Inhibitors), heparin, low molecular weight heparin or warfarin
(more than 1 mg/day) is ongoing or anticipated during the study period. Low-dose
aspirin (up to 100 mg/day) or low-dose warfarin (up to 1 mg/day) is permissible.

- Heparin or low molecular weight heparin within the previous 2 weeks.

- Not recovered from major surgery if conducted prior to the study.

- History of heparin-induced thrombocytopenia, immune mediated thrombocytopenia,
thrombotic thrombocytopenic purpura or other platelet disease, or laboratory evidence
of anti-heparin antibodies.