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Role of Multimodal Areas for Sensory-To-Motor Processing

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Trial Information

Role of Multimodal Areas for Sensory-To-Motor Processing

The role of multimodal brain regions for sensory-to-motor processing is not well understood.
In our recent neuroimaging study with fMRI, we found that multimodal areas such as the
right superior temporal cortex and right dorsal premotor cortex were activated during
sensory instructed movements. These regions might contribute to extract common features or
concepts from sensory stimuli, but we do not have firm experimental evidence yet. In order
to investigate the functional roles of multimodal brain regions further, we propose to apply
a transcranial magnetic stimulation (TMS) technique. TMS can create transient brain lesions
allowing functional mapping of cortical regions. In this protocol, by stimulating the
multimodal areas using TMS, we will determine the functional role of these areas.

Inclusion Criteria


Forty normal volunteers will be included. Normal volunteers would be recruited from
people who are registered as HMCS Normal Volunteers. All subjects participating in this
study should have a valid Clinical Center Medical Record Number. Procedures for the
experiment will follow the Standard Operating Procedures of HMCS TMS group.


Contraindications for TMS;

Magnetic stimulation will not be performed in people who have pacemakers, implanted pumps
or stimulators, or have metal objects inside the eye or skull. If the participants find
the procedures too uncomfortable, they may discontinue the study at any time. Brain
functions at a development stage are out of scope of this particular experiment. In this
study, subjects 18 years or older will be included.

Contraindications for MRI;

Pacemakers, brain stimulators, dental implants or metallic braces, aneurysm clips (metal
clips on the wall of a large artery), metallic prostheses (including metal pins and rods,
heart valves, and cochlear implants), permanent eyeliner, insulin pump, or shrapnel
fragments. Welders and metal workers are also at risk for injury because of possible
small metal fragments in the eye which they may be unaware. Subjects will be screened for
these contraindications prior to the study.

Subjects with previous or current neuropsychiatric disorders will be excluded. Patients
with MRI findings consistent with organic brain lesions such as brain tumors, stroke, or
trauma will be excluded. Subjects not capable of giving informed consent will be

We will not scan pregnant women with MRI because safety of high magnetic field to fetus is
not established. Therefore, we will administer a urine pregnancy test for any female
subject of childbearing potential prior to MRI scan. Brain functions at a developmental
stage are out of scope of this particular experiment. In this study, subjects aged 18
years or older will be included.

Type of Study:


Study Design:



United States: Federal Government

Study ID:




Start Date:

February 2003

Completion Date:

January 2006

Related Keywords:

  • Healthy
  • Transcranial Magnetic Stimulation
  • Counting
  • Sensorimotor Integration
  • Superior Temporal Cortex
  • Dorsal Premotor Cortex
  • Healthy Volunteer
  • HV



National Institute of Neurological Disorders and Stroke (NINDS) Bethesda, Maryland  20892