A Phase II Study Of Docetaxel And Capecitabine In Patients With Measurable Metastatic Adenocarcinoma Of The Stomach And Gastroesophageal Junction
- Determine the objective tumor response rate in patients with metastatic gastric or
gastroesophageal junction adenocarcinoma treated with docetaxel and capecitabine.
- Determine the time to progression in patients treated with this regimen.
- Determine the overall survival in patients treated with this regimen.
- Determine the toxic effects of this regimen in these patients.
- Determine whether interleukin-1 polymorphisms are present among patients who have
weight loss vs no weight loss, and their relationship to a poor prognosis.
- Assess the quality of life and swallowing uniscale during chemotherapy in these
OUTLINE: Patients receive docetaxel IV over 1 hour on day 1 and oral capecitabine twice
daily on days 1-14. Courses repeat every 21 days for up to 2 years in the absence of disease
progression or unacceptable toxicity.
Quality of life is assessed at baseline, at each tumor measurement, and at the end of
Patients are followed every 3 months until disease progression and then every 6 months until
3 years from registration.
PROJECTED ACCRUAL: A total of 15-43 patients will be accrued for this study within 24
Masking: Open Label, Primary Purpose: Treatment
Proportion of successes
Aminah Jatoi, MD
United States: Federal Government
|CCOP - Wichita||Wichita, Kansas 67214-3882|
|CCOP - Metro-Minnesota||Saint Louis Park, Minnesota 55416|
|Fairview Ridges Hospital||Burnsville, Minnesota 55337|
|Mercy and Unity Cancer Center at Mercy Hospital||Coon Rapids, Minnesota 55433|
|Fairview Southdale Hospital||Edina, Minnesota 55435|
|Mercy and Unity Cancer Center at Unity Hospital||Fridley, Minnesota 55432|
|Minnesota Oncology Hematology, PA - Maplewood||Maplewood, Minnesota 55109|
|Virginia Piper Cancer Institute at Abbott - Northwestern Hospital||Minneapolis, Minnesota 55407|
|Hubert H. Humphrey Cancer Center at North Memorial Outpatient Center||Robbinsdale, Minnesota 55422-2900|
|Park Nicollet Cancer Center||St. Louis Park, Minnesota 55416|
|United Hospital||St. Paul, Minnesota 55102|
|Ridgeview Medical Center||Waconia, Minnesota 55387|
|Minnesota Oncology Hematology, PA - Woodbury||Woodbury, Minnesota 55125|
|Via Christi Cancer Center at Via Christi Regional Medical Center||Wichita, Kansas 67214|
|Southwest Medical Center||Liberal, Kansas 67901|
|Cancer Center of Kansas, PA - Dodge City||Dodge City, Kansas 67801|
|Cancer Center of Kansas, PA - Chanute||Chanute, Kansas 66720|
|Cancer Center of Kansas, PA - El Dorado||El Dorado, Kansas 67042|
|Cancer Center of Kansas, PA - Kingman||Kingman, Kansas 67068|
|Cancer Center of Kansas, PA - Newton||Newton, Kansas 67114|
|Cancer Center of Kansas, PA - Parsons||Parsons, Kansas 67357|
|Cancer Center of Kansas, PA - Pratt||Pratt, Kansas 67124|
|Cancer Center of Kansas, PA - Salina||Salina, Kansas 67401|
|Cancer Center of Kansas, PA - Wellington||Wellington, Kansas 67152|
|Cancer Center of Kansas, PA - Wichita||Wichita, Kansas 67214|
|Associates in Womens Health, PA - North Review||Wichita, Kansas 67208|
|Cancer Center of Kansas, PA - Medical Arts Tower||Wichita, Kansas 67208|
|Cancer Center of Kansas, PA - Winfield||Winfield, Kansas 67156|