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Acquisition of Blood, Bone Marrow, Tumor, or Tissue Samples


N/A
18 Years
N/A
Not Enrolling
Both
Neoplasms, Precancerous Conditions

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Trial Information

Acquisition of Blood, Bone Marrow, Tumor, or Tissue Samples


Patients will be evaluated at NNMC Clinics. Blood samples may be collected at the initial
visit and at follow-up visits. Tumor samples may be obtained by fine needle aspirate, by
removal of pleural or peritoneal fluid, or by excisional biopsy, or other procedure. In
general, biopsy tissue will be obtained as an additional sample at the time of a medically
indicated procedure. In some cases, a biopsy may be performed only to obtain a research
sample providing the tumor is accessible with a minimal risk to the patient. Specific risks
will be described in a separate consent to be obtained at the time of the biopsy. Tumor
samples and blood samples will be processed and/or stored for use in research efforts in the
laboratories of the Medical Oncology Branch, Experimental Transplant and Immunology Branch,
or Genetics Branch, Center for Cancer Research, NCI at Navy and NIH.

Inclusion Criteria


- INCLUSION CRITERIA:

Patients must have a performance status of ECOG greater than or equal to 3 for admission
to this protocol.

Subjects must be at least 18 years old.

Patients with any malignancy, high-risk, pre-malignant condition (for example, colonic
polyps, cervical dysplasia, atypical ductal hyperplasia or oral leukoplakia), undergoing
reduction mammoplasty or prophylactic mastectomy are eligible.

Patients requiring a surgical procedure for any medical indication can be included on
study. These patients would be considered normal donors (no diagnosis of cancer).

Patients requiring biopsy or any procedure for any medical indication can be included on
study. These patients will be considered normal donors (no diagnosis of cancer).

Patients not requiring biopsy for a medical indication can be included on the study solely
for the purpose of obtaining research samples, including blood, pleural fluid, or
peritoneal fluid, or biopsy samples, providing the biopsy or aspiration procedure is of
minimal risk, i.e., fine needle aspirate, bone marrow aspirate, or excisional biopsy.

Type of Study:

Observational

Study Design:

N/A

Principal Investigator

Kevin A Camphausen, M.D.

Investigator Role:

Principal Investigator

Investigator Affiliation:

National Cancer Institute (NCI)

Authority:

United States: Federal Government

Study ID:

020258

NCT ID:

NCT00043615

Start Date:

July 2002

Completion Date:

April 2012

Related Keywords:

  • Neoplasms
  • Precancerous Conditions
  • Angiogenesis
  • Drug Resistance
  • Signal Transduction
  • EGFR
  • Survival Factors
  • Malignancy
  • Pre-Cancer Condition
  • Cancer Risk
  • Neoplasms
  • Precancerous Conditions

Name

Location

National Institutes of Health Clinical Center, 9000 Rockville PikeBethesda, Maryland  20892
National Naval Medical CenterBethesda, Maryland  20889