Inclusion Criteria

- INCLUSION CRITERIA:

Patients must have a performance status of ECOG greater than or equal to 3 for admission
to this protocol.

Subjects must be at least 18 years old.

Patients with any malignancy, high-risk, pre-malignant condition (for example, colonic
polyps, cervical dysplasia, atypical ductal hyperplasia or oral leukoplakia), undergoing
reduction mammoplasty or prophylactic mastectomy are eligible.

Patients requiring a surgical procedure for any medical indication can be included on
study. These patients would be considered normal donors (no diagnosis of cancer).

Patients requiring biopsy or any procedure for any medical indication can be included on
study. These patients will be considered normal donors (no diagnosis of cancer).

Patients not requiring biopsy for a medical indication can be included on the study solely
for the purpose of obtaining research samples, including blood, pleural fluid, or
peritoneal fluid, or biopsy samples, providing the biopsy or aspiration procedure is of
minimal risk, i.e., fine needle aspirate, bone marrow aspirate, or excisional biopsy.