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Cell Cycle Kinetics in Vivo in Patients With Hematologic Malignancies Studied by Iododeoxyuridine and Bromodeoxyuridine Labelling


N/A
18 Years
N/A
Not Enrolling
Both
Hematologic Malignancies

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Trial Information

Cell Cycle Kinetics in Vivo in Patients With Hematologic Malignancies Studied by Iododeoxyuridine and Bromodeoxyuridine Labelling


Cell cycle parameters include LI, Ts, Tc, T dpot, changes in these parameters, and
differences between normal and leukemic cells in patients with hematologic malignancy prior
to and following treatment.

Inclusion Criteria


Histologic proof of one of:

- AML, ALL, or AUL

- MDS or CMML

- CML

- OR undergoing bone marrow transplantation.

Participants should be:

- off therapy for at least two weeks

- At least 18 years old or older

- Using adequate contraception if of child-bearing capability.

Type of Study:

Interventional

Study Design:

Allocation: Non-Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic

Principal Investigator

Michael Andreeff, MD, PhD

Investigator Role:

Study Chair

Investigator Affiliation:

M.D. Anderson Cancer Center

Authority:

United States: Food and Drug Administration

Study ID:

DM91-102

NCT ID:

NCT00042250

Start Date:

May 1992

Completion Date:

October 2002

Related Keywords:

  • Hematologic Malignancies
  • Cell Cycle Interphase
  • G0
  • G1
  • G2
  • S Phase
  • Neoplasms
  • Hematologic Neoplasms

Name

Location

M.D. Anderson Cancer CenterHouston, Texas  77030