Breast Cancer Biomarkers Based on Fine Needle Aspirates
- Compare specific biomarkers, including cellular morphology (cytology), proliferation
index (Ki-67), p53 expression, and LOH in chromosome 9p at locus DS9157, in fine needle
aspirate specimens from women at increased vs normal risk of breast cancer.
- Determine whether these specimens are adequate to perform the biomarker assays and
whether this technique could be used in the general outpatient setting.
- Determine whether biomarker levels in these patients are concordant or discordant with
individual clinical risk of breast cancer.
- Determine whether 1 or more biomarkers can distinguish high-risk from control patients.
- Correlate specific biomarkers and changes in biomarker levels with pathologic diagnosis
from the breast biopsy.
OUTLINE: Patients undergo fine needle aspiration of normal appearing breast tissue prior to
the beginning of elective surgery. Specimens are analyzed for the presence of specific
PROJECTED ACCRUAL: Approximately 156 patients will be accrued for this study within 3 years.
Primary Purpose: Screening
Michael H. Torosian, MD
Fox Chase Cancer Center
United States: Federal Government