Primary

Inclusion Criteria:

- Target tumors accessible for percutaneous implantation under CT (and ultrasound if
needed) guidance in any superficial location, sarcoma, tumors of oral/oro-pharyngeal
cavity, tumors with extensive pelvic involvement, or liver metastasis.

- Patient has failed prior surgery or chemotherapy or radiation therapy and the tumor
is refractory.

- Tumor mass is not immediately adjacent to, or directly invading a major vessel or
hollow viscus such that tumor necrosis could result in hemorrhage or perforation.

- Patient has not received prior chemotherapy for at least 4 weeks and patient has
recovered from toxicity.

- Patient has an ECOG performance status of 0-3 (Karnofsky 30 or higher).

- If patients have received radiotherapy to sites of disease other than the one planned
for insertion of the light delivery catheter, then the patient must have no current
local or systemic toxicity from the prior radiation.

- Patient has recovered from all previous surgery in the judgment of the Principal
Investigator.

- Patient has not been treated with any biologics (excluding hormones) at least 4 weeks
prior to the screening and patient has recovered from any toxicity.

- Age 18 or older.

- Minimum life expectancy of 12 weeks.

- Ability to provide informed consent.

- All tumors must:

- have a minimum dimension that exceeds 4 x 2.8 cm;

- have a shape and location such that the mid-point on the light delivery catheter
will be greater than 2.0 cm from any structure which, if damaged by PDT
treatment, would result in pain or injury to the patient.

Exclusion Criteria:

- History of cardiovascular abnormalities, including, myocardial infarction in the last
6 months, arrhythmias, uncontrolled congestive heart failure;

- History of ongoing, significant active medical illness that might create a risk for
the patient, in the opinion of the Investigator;

- History of known or suspected porphyria;

- Concomitant use of other drugs known to produce skin photosensitivity;

- Women who are pregnant or lactating;

- Hematopoietic abnormalities from the baseline examination, as evidenced by the
following laboratory values (US Units):Hemoglobin <10 g/dL; White blood cell (WBC)
count <2500/mm3;Neutrophil count < or = 1500/uL;Platelet count < or = 100,000/mm3;

- Renal or liver function abnormalities from the baseline examination, as evidenced by
the following laboratory values(US Units):Serum Creatinine >2.0 mg/dL;Total bilirubin
> 2.0 mg/dL; SGOT (AST) > 3x the ULN;SGPT (ALT) > 3x the ULN; GGT> 3x the ULN