Inclusion Criteria:

- Histologically confirmed advanced solid tumor for which no standard therapy exists

- At least 1 measurable tumor lesion (at least 2 cm) not previously irradiated

- No history of brain metastases

- Negative brain CT/MRI required for patients with signs and symptoms suspicious
for brain metastases

- Performance status - ECOG 0-1

- WBC greater than 3,000/mm^3

- Absolute neutrophil count greater than 1,500/mm^3

- Platelet count greater than 100,000/mm^3

- Hemoglobin greater than 10 g/dL

- No history of bleeding diathesis

- Bilirubin no greater than 1.5 times upper limit of normal (ULN)

- ALT less than 2.5 times ULN

- Creatinine less than 1.5 mg/dL

- Creatinine clearance greater than 60 mL/min

- No concurrent uncontrolled medical or psychiatric disorders

- No severe iodine allergy

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- At least 30 days since prior over-the-counter, anticancer biologic agents (e.g.,
shark cartilage)

- No concurrent over-the-counter, anticancer biologic agents (e.g., shark cartilage)

- At least 3 weeks since prior cytotoxic or cytostatic agents (6 weeks for nitrosoureas
or mitomycin)

- Patients with ECOG performance status 0:

- Any number of prior chemotherapy regimens allowed

- Patients with ECOG performance status 1:

- No more than 3 prior chemotherapy regimens for metastatic or recurrent disease

- The same drug given on a different schedule does not count as a different
regimen

- Prior adjuvant chemotherapy for non-metastatic disease or as part of a
concurrent chemoradiotherapy protocol is allowed but does not count as part of
the 3-regimen limit

- See Disease Characteristics

- See Chemotherapy

- At least 3 weeks since prior radiotherapy to nonindicator lesions

- No concurrent radiotherapy

- At least 24 hours since prior minor surgery (e.g., central venous catheter placement)

- At least 4 weeks since prior major surgery (e.g., laparotomy, thoracotomy, or
craniotomy)

- At least 30 days since prior anticancer herbal remedies

- At least 30 days since prior investigational agents

- No concurrent anticancer herbal remedies

- No other concurrent investigational or anticancer medication