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Open Label Controlled Trial of Gluten-Free Diet in Patients With Gluten-Sensitivity and Cerebellar Ataxia


N/A
N/A
N/A
Not Enrolling
Both
Celiac Disease, Cerebellar Ataxia, Healthy

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Trial Information

Open Label Controlled Trial of Gluten-Free Diet in Patients With Gluten-Sensitivity and Cerebellar Ataxia


In many patients with cerebellar ataxia, the etiology is unknown. Sensitivity to gluten
(wheat protein) has been suggested as a cause for cerebellar ataxia even in the absence of
malabsorption symptoms or intestinal pathology. However, the prevalence of gluten
sensitivity in patients presenting with cerebellar ataxia is unknown and the effect of
gluten-free diet on gluten sensitivity-associated cerebellar ataxia has not been
systematically studied. The aim of this project is: 1) To identify gluten sensitive
cerebellar ataxia patients attending the Human Motor Control Clinic at the NIH using tests
for celiac disease antibodies as a screening method. 2) To conduct open-label controlled
clinical trial to assess the efficacy of gluten-free diet in the patients identified using a
detailed cerebellar ataxia scale as an objective clinical measure.

Inclusion Criteria


Patients with sporadic cerebellar ataxia of unknown etiology.

CONTROL PATIENTS:

Patients with genetically confirmed cerebellar ataxia (SCA1,2,3,6, and 7, Friedreich's
ataxia) or cerebellar ataxia due to known cause (e.g., cerebellar infarct, cerebellar
degeneration secondary to alcohol abuse).

AGE AND SEX-MATCHED NORMAL SUBJECTS:

With no neurological or psychiatric disease and no medical or family history of celiac
disease.

Type of Study:

Observational

Study Design:

N/A

Authority:

United States: Federal Government

Study ID:

010003

NCT ID:

NCT00006492

Start Date:

November 2000

Completion Date:

December 2002

Related Keywords:

  • Celiac Disease
  • Cerebellar Ataxia
  • Healthy
  • Celiac Disease
  • Cerebellar Ataxia
  • Gluten-Free Diet
  • Ataxia
  • Celiac Disease
  • Cerebellar Ataxia

Name

Location

National Institute of Neurological Disorders and Stroke (NINDS)Bethesda, Maryland  20892