A Phase I/II Trial of Conformal Radiotherapy and Hyperbaric Oxygen for Patients With Newly Diagnosed Glioblastoma
OBJECTIVES: I. Determine the feasibility and toxicity of hyperbaric oxygen combined with
conformal radiotherapy in patients with newly diagnosed glioblastoma multiforme. II.
Determine the efficacy of this regimen in terms of radiographic tumor response, time to
tumor progression, and survival in these patients.
OUTLINE: Within 2 weeks after surgery, patients receive hyperbaric oxygen over 90 minutes
once daily, followed by conformal radiotherapy twice daily 5 days a week for 17 days in the
absence of unacceptable toxicity. Patients are followed within 2 weeks and then every 2
PROJECTED ACCRUAL: A total of 5-10 patients will be accrued for this study within 1 year.
Primary Purpose: Treatment
Ronald E. Warnick, MD
Barrett Cancer Center
United States: Federal Government
|Barrett Cancer Center, The University Hospital||Cincinnati, Ohio 45219|