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Lung Screening Study

55 Years
74 Years
Open (Enrolling)
Lung Cancer

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Trial Information

Lung Screening Study

OBJECTIVES: I. Compare the efficacy of screening spiral CT scan and screening chest x-ray in
detecting lung cancer in current or former smokers at high risk for lung cancer.

OUTLINE: This is a randomized, multicenter study of lung cancer screening. Patients are
randomized to one of two screening arms. Arm I: Patients undergo one spiral CT scan. Arm II:
Patients undergo one chest x-ray. Patients and their primary care physicians are notified of
test results within 3 weeks of the exam.

PROJECTED ACCRUAL: A total of 3,000 participants (1,500 per screening arm) will be accrued
for this study at six screening centers (500 per center) by October 31, 2000.

Inclusion Criteria

DISEASE CHARACTERISTICS: See General Eligibility Criteria

PATIENT CHARACTERISTICS: Age: 55 to 74 Patients with a cigarette smoking history of at
least 30 pack-years Current smoker OR Smoker who has quit smoking within the past 10 years
No known prior history of lung cancer

PRIOR CONCURRENT THERAPY: No concurrent therapy for any cancer except nonmelanomatous skin
cancer No prior removal of any portion of the lungs No concurrent participation in other
cancer screening trial, including PLCO No concurrent participation in a primary cancer
prevention trial other than a smoking cessation trial

Type of Study:


Study Design:

Primary Purpose: Screening

Principal Investigator

John K. Gohagan, PhD, FACE

Investigator Role:

Study Chair

Investigator Affiliation:

National Cancer Institute (NCI)


United States: Federal Government

Study ID:




Start Date:

August 2000

Completion Date:

Related Keywords:

  • Lung Cancer
  • non-small cell lung cancer
  • small cell lung cancer
  • Lung Neoplasms



University of Alabama Comprehensive Cancer Center Birmingham, Alabama  35294
Vincent T. Lombardi Cancer Research Center, Georgetown University Washington, District of Columbia  20007
University of Minnesota Cancer Center Minneapolis, Minnesota  55455
Washington University School of Medicine Saint Louis, Missouri  63110
Henry Ford Hospital Detroit, Michigan  48202
Marshfield Clinic Marshfield, Wisconsin  54449