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Phase I Trial of SU5416 in Combination With Weekly Paclitaxel in Patients With Advanced Malignancies


Phase 1
18 Years
N/A
Not Enrolling
Both
Unspecified Adult Solid Tumor, Protocol Specific

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Trial Information

Phase I Trial of SU5416 in Combination With Weekly Paclitaxel in Patients With Advanced Malignancies


OBJECTIVES:

- Determine the maximum tolerated dose of SU5416 when combined with paclitaxel in
patients with advanced malignancies.

- Determine the toxicities and pharmacokinetics of this regimen in these patients.

- Determine the effects of this regimen on a variety of histological and molecular
biomarkers of angiogenesis, including in vitro activity assays of endothelial cell
proliferation, migration, and invasion.

OUTLINE: This is a dose escalation study of SU5416.

Patients receive SU5416 IV over 1 hour twice weekly during the first week. During subsequent
courses, SU5416 is administered on days 1, 4, 8, 11, 15, 18, 22, and 25. Paclitaxel begins
on the second week of therapy and is administered IV over 1 hour on days 1, 8, 15, and 22.
Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of SU5416 until the maximum tolerated dose
(MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 6 patients
experience dose limiting toxicity.

PROJECTED ACCRUAL: Approximately 24 patients will be accrued for this study within 12-18
months.

Inclusion Criteria


DISEASE CHARACTERISTICS:

- Histologically or cytologically proven advanced malignancy for which no satisfactory
treatment exists

- Must have tumor accessible by biopsy

- Minimum of 1 baseline biopsy required

- No brain metastases or primary CNS tumor

PATIENT CHARACTERISTICS:

Age:

- 18 and over

Performance status:

- WHO 0-2

Life expectancy:

- At least 3 months

Hematopoietic:

- Absolute neutrophil count at least 1,500/mm3

- Platelet count at least 100,000/mm3

Hepatic:

- SGOT and SGPT less than 2 times upper limit of normal unless due to presence of tumor

- Bilirubin normal

Renal:

- Creatinine no greater than 1.5 mg/dL

- Creatinine clearance greater than 60 mL/min

Cardiovascular:

- No uncompensated coronary artery disease by ECG or physical examination

- No myocardial infarction or severe unstable/angina within the past 6 months

- No severe peripheral vascular disease associated with diabetes mellitus

- No severe deep vein or arterial thrombosis within the past 3 months

Pulmonary:

- No pulmonary embolism within the past 3 months

Other:

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception

- No unstable or severe concurrent medical condition

- No active uncontrolled infection

- No history of allergic reaction to paclitaxel or Cremophor

- No greater than grade 1 peripheral neuropathy

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- No prior SU5416

Chemotherapy:

- No prior paclitaxel

- Greater than 4 weeks since prior chemotherapy (6 weeks for nitrosourea or mitomycin)
and recovered

Endocrine therapy:

- Not specified

Radiotherapy:

- Greater than 4 weeks since prior radiotherapy and recovered

Surgery:

- See Disease Characteristics

Other:

- Recovered from any prior investigational agents

- No other concurrent investigational agents

Type of Study:

Interventional

Study Design:

Primary Purpose: Treatment

Principal Investigator

Przemyslaw W. Twardowski, MD

Investigator Role:

Study Chair

Investigator Affiliation:

Beckman Research Institute

Authority:

United States: Federal Government

Study ID:

CDR0000068191

NCT ID:

NCT00006257

Start Date:

November 2000

Completion Date:

Related Keywords:

  • Unspecified Adult Solid Tumor, Protocol Specific
  • unspecified adult solid tumor, protocol specific

Name

Location

Cancer Center and Beckman Research Institute, City of HopeDuarte, California  91010-3000
USC/Norris Comprehensive Cancer Center and HospitalLos Angeles, California  90033-0804
University of California Davis Cancer CenterSacramento, California  95817