Inclusion Criteria

DISEASE CHARACTERISTICS: Histologically proven advanced solid tumor for which no curative
therapy exists No prior or concurrent primary brain tumor or brain metastasis

PATIENT CHARACTERISTICS: Age: Over 18 Performance status: ECOG 0-1 Life expectancy: At
least 12 weeks Hematopoietic: Granulocyte count at least 1,500/mm3 Platelet count at least
100,000/mm3 No inherited predisposition to hypercoagulation Hepatic: Bilirubin normal SGOT
no greater than 2.5 times upper limit of normal Renal: Creatinine no greater than 1.5
mg/dL Cardiovascular: No uncompensated coronary artery disease on electrocardiogram or
physical examination No myocardial infarction or severe unstable angina within the past 6
months No severe peripheral vascular disease related to diabetes mellitus No deep venous
or arterial thrombosis within the past 3 months No inherited predisposition to thrombosis
Pulmonary: No pulmonary embolism within the past 3 months Other: No other malignancies
within the past 5 years except basal or squamous cell skin cancer or carcinoma in situ of
the cervix No other significant medical illness No serious active infections Not pregnant
or nursing Negative pregnancy test Fertile patients must use effective contraception

PRIOR CONCURRENT THERAPY: Biologic therapy: At least 4 weeks since prior biologic therapy
and recovered No concurrent biologic therapy Chemotherapy: At least 4 weeks since prior
chemotherapy and recovered No other concurrent chemotherapy No prior cisplatin or
irinotecan Endocrine therapy: At least 4 weeks since prior hormonal therapy and recovered
No concurrent hormonal therapy Radiotherapy: At least 4 weeks since prior radiotherapy to
less than 25% bone marrow and recovered No concurrent radiotherapy Surgery: At least 4
weeks since prior surgery and recovered No concurrent surgery Other: No other concurrent
investigational drugs