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N/A
N/A
54 Years
Not Enrolling
Both
Fanconi's Anemia, Myelodysplastic Syndromes, Leukemia, Nonlymphocytic, Acute, Leukemia, Lymphocytic, Acute

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Trial Information


PROTOCOL OUTLINE:

Patients receive cyclophosphamide IV over 1-2 hours on day -6 through -3 and total body
radiotherapy on day -1. Patients undergo allogeneic bone marrow transplantation on day 0.

Inclusion Criteria


- Diagnosis of Fanconi's anemia with the family history and typical phenotype
including: Short stature Hypoplastic radii Skin pigmentation Renal anomalies
Chromosomal fragility

- Evidence of Fanconi's myelodysplastic syndrome Bone marrow dysplasia of all 3 marrow
cell lines AND Clonal cytogenetic abnormalities demonstrable in marrow cells

- First complete remission following therapy for Fanconi's acute leukemia allowed

- Must have related histocompatible donor No evidence of excessive in vitro chromosome
fragility typical of Fanconi's anemia Normal CBC and bone marrow

Type of Study:

Interventional

Study Design:

Primary Purpose: Treatment

Principal Investigator

Daniel J. Weisdorf

Investigator Role:

Study Chair

Investigator Affiliation:

Fairview University Medical Center

Authority:

Unspecified

Study ID:

199/15100

NCT ID:

NCT00005892

Start Date:

March 2000

Completion Date:

Related Keywords:

  • Fanconi's Anemia
  • Myelodysplastic Syndromes
  • Leukemia, Nonlymphocytic, Acute
  • Leukemia, Lymphocytic, Acute
  • Fanconi's anemia
  • acute leukemia
  • acute lymphocytic leukemia
  • acute myeloid leukemia
  • acute undifferentiated leukemia
  • adult acute lymphoblastic leukemia
  • adult acute lymphoblastic leukemia in remission
  • adult acute myeloid leukemia
  • adult acute myeloid leukemia in remission
  • aplastic anemia
  • childhood acute lymphoblastic leukemia
  • childhood acute lymphoblastic leukemia in remission
  • childhood acute myeloid leukemia
  • childhood acute myeloid leukemia in remission
  • de novo myelodysplastic syndrome
  • hematologic disorders
  • hematopoietic/lymphoid cancer
  • leukemia
  • myelodysplastic syndrome
  • oncologic disorders
  • previously treated myelodysplastic syndrome
  • rare disease
  • secondary myelodysplastic syndrome
  • Anemia
  • Fanconi Anemia
  • Fanconi Syndrome
  • Leukemia
  • Leukemia, Lymphoid
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma
  • Leukemia, Myeloid, Acute
  • Myelodysplastic Syndromes
  • Preleukemia

Name

Location

Fairview University Medical CenterMinneapolis, Minnesota  55455