Inclusion Criteria

PROTOCOL ENTRY CRITERIA:

--Disease Characteristics--

Clinically confirmed immune thrombocytopenic purpura (ITP) Platelet count less than
75,000/mm3 on two occasions at least 1 week apart within past month

Normal to increased numbers of megakaryocytes on bone marrow examination within past 6
months

Failed prior steroid therapy (i.e., unable to achieve sustained platelet count greater
than 75,000/mm3)

No drug associated ITP

No B cell malignancies

No evidence of disseminated intravascular coagulation (DIC)

--Prior/Concurrent Therapy--

Endocrine therapy: Concurrent steroids allowed as long as platelet count is less than
75,000/mm3 and dose is not changed within past 2 weeks or during study

Other:

- No other concurrent medical therapy for immune thrombocytopenia purpura (ITP)

- At least 2 weeks since prior therapy for ITP (except steroids)

- At least 4 weeks since prior cyclosporine

--Patient Characteristics--

Performance status: ECOG 0-2

Life expectancy: At least 6 months

Renal: Creatinine no greater than 2.0 mg/dL

Cardiovascular: No congestive heart failure or symptomatic coronary insufficiency

Other:

- No clinically significant bleeding (i.e., other than mild mucosal bleeding or
petechiae)

- No sepsis or fever

- No active infection requiring therapy

- No active chronic viral infection

- HIV negative

- No other concurrent or prior malignancy within past 5 years except squamous or basal
cell carcinoma of the skin or carcinoma in situ of the cervix

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception