Magnetic Resonance Correlates of Glioma Tumor Burden
OBJECTIVES: I. Determine whether proton magnetic resonance spectroscopic imaging (1H-MRSI)
and diffusion magnetic resonance imaging (DI) measures of glioma cell burden correlate with
histopathologically measured cell counts in glioma patients who are scheduled to undergo
surgical resection. II. Determine whether 1H-MRSI and DI measures of glioma cell burden are
invariant over the short term (1 week) as steroid dose is increased in these patients.
OUTLINE: Part I: Patients who are scheduled to have surgical resection of brain tumor
undergo conventional magnetic resonance imaging (MRI), proton magnetic resonance
spectroscopic imaging (1H-MRSI), and diffusion magnetic resonance imaging (DI) within 1 week
before resection. Patients undergo conventional MRI within 72 hours after completion of
surgical resection. Image characteristics of the resected tissue are correlated with
histopathological measures. Part II: Patients who have clinical indications for increasing
the dexamethasone dose are treated on part II of the study. Patients are stratified by
status of steroid treatment (steroid naive vs prior steroid management). Patients undergo
conventional MRI, 1H-MRSI, and DI within 2 days before and within 4-7 days after increasing
the dexamethasone dose. Image characteristics on films taken before and after increasing the
dexamethasone dose are compared.
PROJECTED ACCRUAL: A total of 75 patients will be accrued for part I of the study and a
total 40 patients (20 per stratum) will be accrued for part II of the study within 4 years.
Primary Purpose: Diagnostic
Jeffry Alger, PhD
Jonsson Comprehensive Cancer Center
United States: Federal Government
|Jonsson Comprehensive Cancer Center, UCLA||Los Angeles, California 90095-1781|