Inclusion Criteria

DISEASE CHARACTERISTICS:

- Histologically confirmed invasive cutaneous melanoma

- Breslow thickness at least 1.0 mm

- Primary site must be on head, neck, trunk or extremity

- No more than 90 days since biopsy

- Protocol A:

- One or more sentinel lymph nodes with histologic or immunohistochemical evidence
of metastatic melanoma

- Prior regional lymph node dissection

- Protocol B:

- Sentinel lymph nodes with no histologic or immunohistochemical evidence of
metastatic melanoma

- Sentinel lymph node positive by reverse transcriptase polymerase chain reaction

- No prior wide local excision of the primary tumor with a margin greater than 1.5 cm

- No primary melanoma involving the eye or mucous membranes

- No clinical evidence of satellite lesions or intransit, regional nodal, or distant
metastases

- No second primary invasive melanoma

- No prior surgery in the region of the primary draining nodal basin that would disrupt
normal lymphatic drainage patterns (e.g., skin grafts, tissue transfers or flaps, or
lymph node dissections)

PATIENT CHARACTERISTICS:

Age:

- 18 to 70

Performance status:

- Karnofsky 70-100%

Life expectancy:

- At least 10 years

Hematopoietic:

- WBC at least 3,000/mm^3

- Absolute granulocyte count at least 1,500/mm^3

- Platelet count at least 70,000/mm^3

- Hemoglobin at least 10.0 g/dL

Hepatic:

- Bilirubin less than 2.0 mg/dL

- SGOT/SGPT less than 3 times upper limit of normal (ULN)

- Alkaline phosphatase less than 3 times ULN

- No severe decompensated liver disease (e.g., cirrhosis or autoimmune hepatitis)

- No other significant liver disease that would preclude study participation

Renal:

- Creatinine normal

Cardiovascular:

- No cardiovascular disease (e.g., angina or congestive heart failure)

- No myocardial infarction within the past year

- No tachyarrhythmias

Pulmonary:

- No severe debilitating pulmonary disease (e.g., chronic obstructive pulmonary
disease)

Other:

- No hypersensitivity to interferon alfa-2b or related compounds or any component of
the injection

- No major depression or other major psychiatric illness

- No thyroid disorder with thyroid function that is not maintained within the normal
range with medications

- No autoimmune disease

- No primary or secondary immunodeficiencies

- No severe diabetes mellitus prone to ketoacidosis

- No significant retinal abnormalities

- No evidence of infection

- No other malignancy within the past 5 years except basal cell or squamous cell skin
cancer, carcinoma in situ of the cervix, or stage I laryngeal cancer

- No other medical condition that would preclude study participation

- Not pregnant or nursing

- Negative pregnancy test

- Fertile patients must use effective contraception during and for 6 months after the
study

PRIOR CONCURRENT THERAPY:

Biologic therapy:

- No prior immunotherapy

Chemotherapy:

- No prior chemotherapy

Endocrine therapy:

- At least 6 months since prior oral or parenteral steroids

Radiotherapy:

- No prior radiotherapy

Surgery:

- See Disease Characteristics

- No prior organ transplantation

Other:

- At least 6 months since prior immunosuppressants

- No concurrent immunosuppressants resulting from prior organ transplantation